CD28 is expressed by macrophages with anti‐inflammatory potential and limits their T‐cell activating capacity
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048806
Abstract: CD28 expression is generally considered to be T lymphocyte specific. We have previously shown CD28 mRNA expression in M‐CSF‐dependent anti‐inflammatory monocyte‐derived macrophages (M‐MØ), and now demonstrate that CD28 cell surface expression is higher in M‐MØ… read more here.
Keywords: anti inflammatory; capacity; cd28; expression ... See more keywords
Altered expression of costimulatory molecules in dementias
Sign Up to like & getrecommendations! Published in 2021 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-021-01297-1
Abstract: Although the expression of co-stimulatory molecules plays an important role in the immune system, only little is known about their regulation in dementias. Therefore, we determined the expression of CD28, ICOS (CD278) and CTLA-4 (CD152)… read more here.
Keywords: cd8 cells; cd28 icos; cd28; ftd patients ... See more keywords
F-Actin-Driven CD28-CD80 Localization in the Immune Synapse.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.114
Abstract: During immunological synapse (IS) formation, T cell receptor (TCR) signaling complexes, integrins, and costimulatory molecules exhibit a particular spatial localization. Here, we develop an agent-based model for the IS formation based on TCR peptide-bound major histocompatibility… read more here.
Keywords: synapse; cd28 cd80; cd80 localization; cd28 ... See more keywords
CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107815
Abstract: SUMMARY Durable humoral immunity against epidemic infectious disease requires the survival of long-lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic programs distinct from short-lived plasma cells (SLPCs); however, the mechanistic basis for this… read more here.
Keywords: cd28 regulates; cd28; survival; lived plasma ... See more keywords
CD8+CD28+/CD8+CD28- T cell equilibrium can predict the active stage for patients with inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2017.03.009
Abstract: BACKGROUND/AIM The balance of blood CD8+CD28+/CD8+CD28- T cells has been verified to be vital for patients with ulcerative colitis (UC), but their role in inflammatory bowel disease (IBD) remains unknown. This investigation aimed to evaluate… read more here.
Keywords: cd28 cell; cd28 cd8; cd8 cd28; cd28 ... See more keywords
Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.08.018
Abstract: BACKGROUND AIMS This study aimed to determine the prognostic value of circulating CD8+CD28- T lymphocytes among breast cancer patients treated with adoptive T-lymphocyte immunotherapy after chemotherapy. METHODS Two hundred and thirty-two breast cancer patients underwent… read more here.
Keywords: breast cancer; cd28; circulating cd8; proportion ... See more keywords
Structural characterization of a dimerization interface in the CD28 transmembrane domain.
Sign Up to like & getrecommendations! Published in 2022 at "Structure"
DOI: 10.1016/j.str.2022.03.004
Abstract: CD28 has a crucial role in regulating immune responses by enhancing T cell activation and differentiation. Recent studies have shown that the transmembrane helix (TMH) of CD28 mediates receptor assembly and activity, but a structural characterization… read more here.
Keywords: structural characterization; cd28; dimerization interface; tmh ... See more keywords
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03385-8
Abstract: CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflammatory response syndrome in humans,… read more here.
Keywords: amino acid; human mouse; mouse cd28; cd28 ... See more keywords
CD8+CD28-T-cells: Key cytotoxic players impacting disease pathogenesis in chronic HBV infection.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20190369
Abstract: During chronic hepatitis B (CHB), CD8+T-cells downregulate CD28, the primary costimulation molecule for T-cell activation. Diverse functional attributes of CD8+CD28-T-cells are suggested in various disease contexts. The present study aimed to characterize CD8+CD28-T-cells in different… read more here.
Keywords: cd28; cell; cd28 cells; hbv ... See more keywords
Association of CTLA-4 and CD28 Gene Polymorphisms with Type 1 Diabetes in South Indian Population
Sign Up to like & getrecommendations! Published in 2019 at "Immunological Investigations"
DOI: 10.1080/08820139.2019.1590395
Abstract: ABSTRACT Each functional gene illustrates the complexity of genetic predisposition to disease; however, it is difficult to bring out these traits with reference to autoimmune diseases like type 1 diabetes (T1D). To find out the… read more here.
Keywords: indian population; ctla; south indian; cd28 ... See more keywords
Discrepant Clinical Significance of CD28+CD8- and CD4+CD25high Regulatory T Cells During the Progression of Hepatitis B Virus Infection.
Sign Up to like & getrecommendations! Published in 2018 at "Viral immunology"
DOI: 10.1089/vim.2018.0035
Abstract: Accumulating evidence demonstrates that CD8+CD28- regulatory T cells increase in chronic viral infection as well as tumorigenesis. However, it is still not clear about their characteristics in hepatitis B virus (HBV) infection. In addition, it… read more here.
Keywords: cd8; infection; regulatory cells; cd28 ... See more keywords