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   Articles with "cd28" as a keyword



CD28 is expressed by macrophages with anti‐inflammatory potential and limits their T‐cell activating capacity

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recommendations! Published in 2020 at "European Journal of Immunology"

DOI: 10.1002/eji.202048806

Abstract: CD28 expression is generally considered to be T lymphocyte specific. We have previously shown CD28 mRNA expression in M‐CSF‐dependent anti‐inflammatory monocyte‐derived macrophages (M‐MØ), and now demonstrate that CD28 cell surface expression is higher in M‐MØ… read more here.

Keywords: anti inflammatory; capacity; cd28; expression ... See more keywords

Altered expression of costimulatory molecules in dementias

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recommendations! Published in 2021 at "European Archives of Psychiatry and Clinical Neuroscience"

DOI: 10.1007/s00406-021-01297-1

Abstract: Although the expression of co-stimulatory molecules plays an important role in the immune system, only little is known about their regulation in dementias. Therefore, we determined the expression of CD28, ICOS (CD278) and CTLA-4 (CD152)… read more here.

Keywords: cd8 cells; cd28 icos; cd28; ftd patients ... See more keywords

F-Actin-Driven CD28-CD80 Localization in the Immune Synapse.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.06.114

Abstract: During immunological synapse (IS) formation, T cell receptor (TCR) signaling complexes, integrins, and costimulatory molecules exhibit a particular spatial localization. Here, we develop an agent-based model for the IS formation based on TCR peptide-bound major histocompatibility… read more here.

Keywords: synapse; cd28 cd80; cd80 localization; cd28 ... See more keywords
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CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.107815

Abstract: SUMMARY Durable humoral immunity against epidemic infectious disease requires the survival of long-lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic programs distinct from short-lived plasma cells (SLPCs); however, the mechanistic basis for this… read more here.

Keywords: cd28 regulates; cd28; survival; lived plasma ... See more keywords

CD8+CD28+/CD8+CD28- T cell equilibrium can predict the active stage for patients with inflammatory bowel disease.

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recommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"

DOI: 10.1016/j.clinre.2017.03.009

Abstract: BACKGROUND/AIM The balance of blood CD8+CD28+/CD8+CD28- T cells has been verified to be vital for patients with ulcerative colitis (UC), but their role in inflammatory bowel disease (IBD) remains unknown. This investigation aimed to evaluate… read more here.

Keywords: cd28 cell; cd28 cd8; cd8 cd28; cd28 ... See more keywords

Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.

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recommendations! Published in 2018 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2017.08.018

Abstract: BACKGROUND AIMS This study aimed to determine the prognostic value of circulating CD8+CD28- T lymphocytes among breast cancer patients treated with adoptive T-lymphocyte immunotherapy after chemotherapy. METHODS Two hundred and thirty-two breast cancer patients underwent… read more here.

Keywords: breast cancer; cd28; circulating cd8; proportion ... See more keywords

Structural characterization of a dimerization interface in the CD28 transmembrane domain.

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recommendations! Published in 2022 at "Structure"

DOI: 10.1016/j.str.2022.03.004

Abstract: CD28 has a crucial role in regulating immune responses by enhancing T cell activation and differentiation. Recent studies have shown that the transmembrane helix (TMH) of CD28 mediates receptor assembly and activity, but a structural characterization… read more here.

Keywords: structural characterization; cd28; dimerization interface; tmh ... See more keywords

Directed Evolution of Multicyclic Peptides Using Yeast Display for Sensitive and Selective Fluorescent Analysis of CD28 on the Cell Surface.

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recommendations! Published in 2025 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.4c05681

Abstract: CD28 is a costimulatory receptor that provides the second signal necessary for T-cell activation and is associated with diseases, including rheumatoid arthritis, asthma, and cancer. Targeting CD28 is crucial for both functional bioanalysis and therapeutic… read more here.

Keywords: cd28; multicyclic peptides; yeast display; sensitive selective ... See more keywords

Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c02136

Abstract: CD28 is a key T cell costimulatory receptor implicated in antitumor immunity and immune-related disorders, yet no small molecule modulators of CD28 have reached clinical development. Here, we report the discovery and characterization of small… read more here.

Keywords: cd28; affinity selection; mass spectrometry; small molecule ... See more keywords

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c10222

Abstract: CD28 is a critical costimulatory receptor involved in T cell activation and immune regulation, making it a compelling target for immunomodulatory therapies. Despite its therapeutic relevance, small molecule CD28 inhibitors remain largely underexplored. To address… read more here.

Keywords: cd28; targeted small; cd28 targeted; spr based ... See more keywords

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-03385-8

Abstract: CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflammatory response syndrome in humans,… read more here.

Keywords: amino acid; human mouse; mouse cd28; cd28 ... See more keywords