Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells
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DOI: 10.1126/sciadv.abo4413
Abstract: Type 1 regulatory T (Tr1) cells represent a subset of IL-10–producing CD4+Foxp3− T cells and play key roles in promoting transplant tolerance. However, no effective pharmacological approaches have been able to induce Tr1 cells in… read more here.
Keywords: tr1; permanent allograft; allograft acceptance; cd28 superagonist ... See more keywords