Computer‐assisted quantification of CD3+ T cells in follicular lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23049
Abstract: The advance of high resolution digital scans of pathology slides allowed development of computer based image analysis algorithms that may help pathologists in IHC stains quantification. While very promising, these methods require further refinement before… read more here.
Keywords: cd3; computer; computerized quantification; quantification method ... See more keywords
OMIP‐079: Cell cycle of CD4+ and CD8+ naïve/memory T cell subsets, and of Treg cells from mouse spleen
Sign Up to like & getrecommendations! Published in 2021 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24509
Abstract: A multicolor flow cytometry panel was designed and optimized to define the following nine mouse T cell subsets: Treg (CD3+ CD4+ CD8− FoxP3+), CD4+ T naïve (CD3+ CD4+ CD8−FoxP3− CD44int/low CD62L+), CD4+ T central memory… read more here.
Keywords: cd4; cd3; cd62l; cd8 ... See more keywords
NAV-003, A Bispecific Antibody Targeting A Unique Mesothelin Epitope and CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250309
Abstract: Mesothelin (MSLN) is a cell surface protein over-expressed in a number of cancer types. Several antibody- and cellular-based MSLN targeting agents have been tested in clinical trials where their therapeutic efficacy has been moderate at… read more here.
Keywords: cd3; mesothelin; bispecific antibody; nav 003 ... See more keywords
Expression of CD3, PD-L1 and CTLA-4 in mammary and extra-mammary Paget disease
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2189-x
Abstract: BackgroundMammary and extra-mammary Paget disease is a rare form of intra-epithelial glandular neoplasm which is characteristically recurrent and necessitates multiple excisions that have an important impact on morbidity. Local immuno-modulating treatments have been applied with… read more here.
Keywords: cd3; extra mammary; disease; expression ... See more keywords
Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of Medicine"
DOI: 10.1007/s11684-021-0835-8
Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. However, several studies showed that blinatumomab has a short plasma half-life due to its low molecular… read more here.
Keywords: cd3; cd19; cd3 cd19; lymphoblastic leukemia ... See more keywords
Dietary Spirulina platensis phycocyanin improves growth, tissue histoarchitecture, and immune responses, with modulating immunoexpression of CD3 and CD20 in Nile tilapia, Oreochromis niloticus
Sign Up to like & getrecommendations! Published in 2022 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.737413
Abstract: Abstract This experiment was performed to examine the impact of dietary Spirulina platensis phycocyanin (SPC) on the growth performance, antioxidant status, histomorphology of certain organs, immune status with analyzing the immunohistochemical expression of CD3 and… read more here.
Keywords: cd3; growth; cd20; spc supplementation ... See more keywords
T Cell Receptor Clustering - A Mechanism of Signal Transduction
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.235
Abstract: Antigen recognition by the T cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal… read more here.
Keywords: tcr cd3; cd3; cell receptor;
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109375
Abstract: Summary The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable… read more here.
Keywords: tcr cd3; cd3; antigen receptor; cell antigen ... See more keywords
P173 The ART(EFACT) of multicolor flow cytometry. A case of mysterious CD3/CD19 double positive lymphocytes in the flow cytometry crossmatch (FCXM) assay
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.233
Abstract: Aim Over the past 3 months we have been noticing an unusual population of CD3/CD19 double positive (DP) lymphocytes in some flowcytometry crossmatches (FCXM) performed in our HLA lab. Initially, the appearance of these unusual DP… read more here.
Keywords: flow cytometry; cd3 cd19; cd3; fcxm ... See more keywords
The T Cell Antigen Receptor &agr; Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.09.007
Abstract: &NA; Initial molecular details of cellular activation following &agr;&bgr;T cell antigen receptor (TCR) ligation by peptide‐major histocompatibility complexes (pMHC) remain unexplored. We determined the nuclear magnetic resonance (NMR) structure of the TCR&agr; subunit transmembrane (TM)… read more here.
Keywords: cd3; transmembrane domain; tcr agr; tcr ... See more keywords
Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.11.008
Abstract: How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active… read more here.
Keywords: cd3; model tcr; tcr cd3; dissociative model ... See more keywords