Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes
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DOI: 10.1038/s41598-019-45260-6
Abstract: Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that… read more here.
Keywords: cd4 lymphocytes; tcr cd3; mediated activation; cd3 mediated ... See more keywords
Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics
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DOI: 10.1038/srep45839
Abstract: T cell–mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key molecules to modulate T cell functions; however, in many cases,… read more here.
Keywords: cd3; cd3 humanized; entire cd3; humanized mouse ... See more keywords