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   Articles with "cd33" as a keyword



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Evidence of transfusion‐induced reductions in cerebral capillary shunting in sickle cell disease

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recommendations! Published in 2020 at "American Journal of Hematology"

DOI: 10.1002/ajh.25863

Abstract: 2016;30(2):268-273. 5. Lamba J, Chauhan L, Shin M, et al. CD33-Single Nucleotide Polymorphism (CD33-SNP) Score Predicts Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia: Report from Children's Oncology Group AAML0531 Trial. Blood. 2017;130(suppl 1): 3826.… read more here.

Keywords: induced reductions; cd33; reductions cerebral; transfusion induced ... See more keywords

CD33-directed immunotherapy with third-generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and CD33-edited acute myeloid leukemia and hematopoietic stem and progenitor cells.

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recommendations! Published in 2021 at "International journal of cancer"

DOI: 10.1002/ijc.33865

Abstract: Immunotherapies, such as chimeric antigen receptor (CAR) modified T cells and antibody-drug conjugates (ADCs), have revolutionized the treatment of cancer, especially of lymphoid malignancies. The application of targeted immunotherapy to patients with acute myeloid leukemia… read more here.

Keywords: cd33; generation; stem; leukemia ... See more keywords

Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant

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recommendations! Published in 2019 at "Acta Neuropathologica"

DOI: 10.1007/s00401-019-02065-1

Abstract: Genome-wide association studies (GWAS) identified an allele of the microglial CD33 (Siglec-3) cell surface receptor that protects against Alzheimer’s disease (AD). Protected individuals express less full-length CD33 and more alternatively spliced D2-CD33 lacking the amino-terminal… read more here.

Keywords: cd33; alzheimer disease; localization; cell surface ... See more keywords

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.

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recommendations! Published in 2017 at "Experimental hematology"

DOI: 10.1016/j.exphem.2017.06.007

Abstract: Acute myeloid leukemia (AML) develops when there is a block in differentiation and uncontrolled proliferation of myeloid precursors, resulting in bone marrow failure. AML is a clinically, morphologically, and genetically heterogeneous disease, and biological differences… read more here.

Keywords: cd33; adult childhood; acute myeloid; myeloid ... See more keywords

Combinatorial antigen targeting strategies for acute leukemia: application in myeloid malignancy.

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recommendations! Published in 2021 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2021.10.007

Abstract: BACKGROUND AIMS Efforts to safely and effectively treat acute myeloid leukemia (AML) by targeting a single leukemia-associated antigen with chimeric antigen receptor (CAR) T cells have met with limited success, due in part to heterogeneous… read more here.

Keywords: cll; antigen; cd33; myeloid ... See more keywords

Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14

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recommendations! Published in 2020 at "Medical Hypotheses"

DOI: 10.1016/j.mehy.2020.110168

Abstract: Abstract SARS-CoV-2 interaction with the ACE-2 receptor cannot alone explain the demography and remarkable variation in clinical progression of Covid-19 infection. Unlike SARS-CoV, the cause of SARS, several SARS-CoV-2 spike glycans contain sialic acid residues.… read more here.

Keywords: siglec; cd33; severe covid; sars cov ... See more keywords

Development of CD33-Targeted Dual Drug-Loaded Nanoparticles for the Treatment of Pediatric Acute Myeloid Leukemia

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recommendations! Published in 2024 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.4c00672

Abstract: Paediatric acute myeloid leukemia (AML) is a heterogeneous hematological malignancy still heavily reliant on traditional chemotherapeutic approaches. Combination treatments have shown to be a superior approach, but their success is often hindered by side effects… read more here.

Keywords: development cd33; acute myeloid; drug; cd33 targeted ... See more keywords
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Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators.

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recommendations! Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.1c00396

Abstract: CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. Multiple genome-wide association studies (GWAS) have identified genetic variants in the CD33 gene that convey protection from late-onset Alzheimer's… read more here.

Keywords: cd33 pre; pre mrna; cd33; mrna ... See more keywords

A bispecific antibody–drug conjugate targeting CD7 and CD33 shows anti-tumor activity and improved tumor selectivity in an aggressive subtype of acute myeloid leukemia

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recommendations! Published in 2025 at "mAbs"

DOI: 10.1080/19420862.2025.2551205

Abstract: ABSTRACT Acute myeloid leukemia (AML) is a heterogeneous malignancy with poor clinical outcome. Aberrant expression of CD7 in AML patients is linked to shorter overall survival and lack of response to standard of care therapy.… read more here.

Keywords: cd7; acute myeloid; tumor; myeloid leukemia ... See more keywords

CD33-Specific Chimeric Antigen Receptor T Cells with Different Co-Stimulators Showed Potent Anti-Leukemia Efficacy and Different Phenotype.

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recommendations! Published in 2018 at "Human gene therapy"

DOI: 10.1089/hum.2017.241

Abstract: Acute myeloid leukemia (AML) is a kind of a malignant hematologic tumor caused by uncontrolled repopulation of myeloid hematopoietic stem cells (HSCs). Current therapeutic effects for AML patients are unsatisfactory. In particular, relapsed and refractory… read more here.

Keywords: cd33; antigen; car cells; aml ... See more keywords

Midostaurin abrogates CD33‐directed UniCAR and CD33‐CD3 bispecific antibody therapy in acute myeloid leukaemia

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recommendations! Published in 2019 at "British Journal of Haematology"

DOI: 10.1111/bjh.15975

Abstract: Combinatory therapeutic approaches of different targeted therapies in acute myeloid leukaemia are currently under preclinical/early clinical investigation. To enhance anti‐tumour effects, we combined the tyrosine kinase inhibitor (TKI) midostaurin and T‐cell mediated immunotherapy directed against… read more here.

Keywords: cd33; cell; myeloid leukaemia; acute myeloid ... See more keywords