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   Articles with "cd34" as a keyword



Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

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recommendations! Published in 2024 at "ESC Heart Failure"

DOI: 10.1002/ehf2.15124

Abstract: The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option… read more here.

Keywords: cd34 cells; trial; cd34; myocardial infarction ... See more keywords

Comparison of cord blood CD34 + stem cell expansion in coculture with mesenchymal stem cells overexpressing SDF‐1 and soluble /membrane isoforms of SCF

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recommendations! Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.28797

Abstract: Umbilical cord blood hematopoietic stem cells (UCB HSCs) have been considered for the treatment of hematological malignancies due to their noninvasive collection, greater capacity of expansion, and remarkable tolerance for HLA mismatch in transplantation. On… read more here.

Keywords: cd34; cord blood; expansion; stem ... See more keywords

Large‐Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells

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recommendations! Published in 2017 at "Stem Cells Translational Medicine"

DOI: 10.1002/sctm.17-0057

Abstract: The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor cells has been considered as a potential method to overcome blood supply shortages. Here, we report that… read more here.

Keywords: medicine; cd34; vivo generation; generation human ... See more keywords

Design and Validation of an Automated Process for the Expansion of Peripheral Blood‐Derived CD34+ Cells for Clinical Use After Myocardial Infarction

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recommendations! Published in 2019 at "Stem Cells Translational Medicine"

DOI: 10.1002/sctm.17-0277

Abstract: We previously demonstrated that intracardiac delivery of autologous peripheral blood‐derived CD34+ stem cells (SCs), mobilized by granulocyte‐colony stimulating factor (G‐CSF) and collected by leukapheresis after myocardial infarction, structurally and functionally repaired the damaged myocardial area.… read more here.

Keywords: medicine; cd34; expansion; blood ... See more keywords

CD34 + cell therapy significantly reduces adverse cardiac events, health care expenditures, and mortality in patients with refractory angina

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recommendations! Published in 2020 at "Stem Cells Translational Medicine"

DOI: 10.1002/sctm.20-0046

Abstract: Patients with refractory angina who are suboptimal candidates for further revascularization have improved exercise time, decreased angina frequency, and reduced major adverse cardiac events with intramyocardial delivery of CD34+ cells. However, the effect of CD34+… read more here.

Keywords: cd34 cell; cd34; cell therapy; refractory angina ... See more keywords
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Lack of CD34 produces defects in platelets, microparticles, and lung inflammation

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recommendations! Published in 2020 at "Cell and Tissue Research"

DOI: 10.1007/s00441-020-03243-4

Abstract: Lung innate immune activation results in acute lung inflammation, which is characterized by alveolar barrier disruption and accumulation of cellular lung aggregates comprising neutrophils, platelets, mononuclear cells, and microparticles. CD34 is a sialomucin, with pan-selectin… read more here.

Keywords: cd34; lung injury; platelet; lung inflammation ... See more keywords

CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis

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recommendations! Published in 2024 at "Cell and Tissue Research"

DOI: 10.1007/s00441-024-03892-9

Abstract: Synovial chondromatosis (SC) is a disorder of the synovium characterized by the formation of osteochondral nodules within the synovium. This study aimed to identify the abnormally differentiated progenitor cells and possible pathogenic signaling pathways. Loose… read more here.

Keywords: cd34 cells; synovial chondromatosis; cd34; cd34 synovial ... See more keywords

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

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recommendations! Published in 2021 at "Frontiers of Medicine"

DOI: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy with a high relapse rate in China. Two leukemic myeloblast populations (CD34+CD117dim and CD34+CD117bri) were previously identified in t(8;21) AML, and CD34+CD117dim cell proportion… read more here.

Keywords: cd34 cd117bri; cd34; expression; cd34 cd117dim ... See more keywords

Evaluation of the histologic and immunohistochemical (CD34, glutamine synthetase) findings in idiopathic non-cirrhotic portal hypertension (INCPH)

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recommendations! Published in 2024 at "Hepatology International"

DOI: 10.1007/s12072-024-10654-w

Abstract: Idiopathic non-cirrhotic portal hypertension (INCPH) is a vascular disorder of uncertain origin. Diagnosis can be challenging on liver biopsy. Despite diverse histomorphologic findings documented in literature, studies on the frequency of these findings are lacking.… read more here.

Keywords: idiopathic non; cirrhotic portal; cd34; incph ... See more keywords

Lenalidomide and pomalidomide modulate hematopoietic cell expansion and differentiation in the presence of MSC

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recommendations! Published in 2024 at "International Journal of Hematology"

DOI: 10.1007/s12185-024-03815-y

Abstract: Cytopenia is a well-documented complication in the treatment of hematological malignancies with lenalidomide and pomalidomide. Although prior studies have highlighted direct effects on hematopoietic cells to explain this adverse effect, the involvement of hematopoietic-supportive stroma… read more here.

Keywords: differentiation; expansion differentiation; presence; cd34 ... See more keywords

CD34+ and CD34− MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells

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recommendations! Published in 2024 at "International Journal of Hematology"

DOI: 10.1007/s12185-024-03867-0

Abstract: Despite the introduction of new drugs, multiple myeloma (MM) still remains incurable. We previously reported that CD34+ MM cells, which are clonogenic and self-renewing, are therapy-resistant and persist as a major component of minimal residual… read more here.

Keywords: cd137; cd34 cells; immune checkpoint; cd34 ... See more keywords