Phenotypic characterization of disease‐initiating stem cells in JAK2‐ or CALR‐mutated myeloproliferative neoplasms
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DOI: 10.1002/ajh.26889
Abstract: Myeloproliferative neoplasms (MPN) are characterized by uncontrolled expansion of myeloid cells, disease‐related mutations in certain driver‐genes including JAK2, CALR, and MPL, and a substantial risk to progress to secondary acute myeloid leukemia (sAML). Although behaving… read more here.
Keywords: cd34 cd38; stem; stem cells; disease initiating ... See more keywords
HDAC inhibitor suppresses proliferation and tumorigenicity of drug‐resistant chronic myeloid leukemia stem cells through regulation of hsa‐miR‐196a targeting BCR/ABL1
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.07.017
Abstract: &NA; Failure to eradicate hematologic cancer stem cells (hCSCs) associated with resistance to tyrosine kinase inhibitors such as imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is a clinical challenge that highlights the need… read more here.
Keywords: cd34 cd38; hsa mir; mir 196a; cd38 ... See more keywords
The prognostic effect on childhood acute lymphoblastic leukemia of CD34+CD38− expressed in leukemia cells
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DOI: 10.1080/16078454.2022.2080368
Abstract: ABSTRACT Objective Acute lymphoblastic leukemia is the most common malignant disease in children. CD34 and CD38 are expressed in both normal and leukemia cells, but studies of their prognostic associations in childhood acute lymphoblastic leukemia… read more here.
Keywords: cd34; lymphoblastic leukemia; cd34 cd38; acute lymphoblastic ... See more keywords
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells
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DOI: 10.1182/blood-2018-99-120258
Abstract: Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow associated with poor clinical outcomes. Conventional chemotherapies are effective in debulking the leukemic burden in most AML patients. However, a small population of… read more here.
Keywords: cd34 cd38; expression; kpt 9274; activity ... See more keywords
Identification of an Expanded Immature Cell Population in Human Bone Marrow during Erythroid Responses to ESA Treatment
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DOI: 10.1182/blood-2019-130065
Abstract: Background and aim: Treatment with erythropoietin stimulating agents (ESA) is first-line treatment for anemic low-risk MDS patients, but although clinical variables such as endogenous serum erythropoietin levels have been associated with response, the bone marrow… read more here.
Keywords: cd34 cd38; treatment; esa treatment; mds patients ... See more keywords
Different Subsets of Haematopoietic Cells and Immune Cells in Bone Marrow between Young and Old Donors
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DOI: 10.1182/blood-2020-134758
Abstract: Background Young donors are reported to be associated with better transplant outcomes than old donors in allo-HSCT, but the underlying mechanism is still uncertain. Successful allo-HSCT relies on the rapid reconstitution of donor-derived haematopoietic and… read more here.
Keywords: cd34 cd38; frequency; cd45ra; old donors ... See more keywords
CD34+CD38−CD123+ Leukemic Stem Cell Frequency Predicts Outcome in Older Acute Myeloid Leukemia Patients Treated by Intensive Chemotherapy but Not Hypomethylating Agents
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DOI: 10.3390/cancers12051174
Abstract: The prognostic impact of immunophenotypic CD34+CD38−CD123+ leukemic stem cell (iLSC) frequency at diagnosis has been demonstrated in younger patients treated by intensive chemotherapy, however, this is less clear in older patients. Furthermore, the impact of… read more here.
Keywords: patients treated; cd34 cd38; frequency; intensive chemotherapy ... See more keywords
High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia
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DOI: 10.4252/wjsc.v9.i12.227
Abstract: AIM To evaluate the importance of the CD34+CD38- cell population when compared to the CD34+CD38+/low and CD34+CD38+/high leukemic cell sub-populations and to determine its correlations with leukemia characteristics and known prognostic factors, as well as… read more here.
Keywords: cd38 low; cd34 cd38; cd38; acute myeloid ... See more keywords
Prognostic Impact and Phenotype of Residual Acute Myeloid Leukemia Stem Cells.
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DOI: 10.7754/clin.lab.2021.210821
Abstract: BACKGROUND Leukemia stem cells (LSCs) have been demonstrated to be more therapy-resistant than leukemic blast cells reflecting measurable residual disease (MRD). CD34+CD38- cell frequency is an independent factor for relapse prediction and could therefore be… read more here.
Keywords: myeloid; leukemia stem; cd34 cd38; stem ... See more keywords