Phenotypic characterization of disease‐initiating stem cells in JAK2‐ or CALR‐mutated myeloproliferative neoplasms
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DOI: 10.1002/ajh.26889
Abstract: Myeloproliferative neoplasms (MPN) are characterized by uncontrolled expansion of myeloid cells, disease‐related mutations in certain driver‐genes including JAK2, CALR, and MPL, and a substantial risk to progress to secondary acute myeloid leukemia (sAML). Although behaving… read more here.
Keywords: cd34 cd38; stem; stem cells; disease initiating ... See more keywords
HDAC inhibitor suppresses proliferation and tumorigenicity of drug‐resistant chronic myeloid leukemia stem cells through regulation of hsa‐miR‐196a targeting BCR/ABL1
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.07.017
Abstract: &NA; Failure to eradicate hematologic cancer stem cells (hCSCs) associated with resistance to tyrosine kinase inhibitors such as imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is a clinical challenge that highlights the need… read more here.
Keywords: cd34 cd38; hsa mir; mir 196a; cd38 ... See more keywords
Genetic instability in HSPC subpopulations of umbilical cord blood from patients with childhood acute lymphoblastic leukemia
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DOI: 10.1038/s41598-025-88204-z
Abstract: Preleukemic stem cells (PSC) containing preleukemic fusion genes (PFG) arise prenatally and represent the initial stage of acute lymphoblastic leukemia (ALL) development. Despite widespread efforts, the cell of origin of PFG is still unclear. For… read more here.
Keywords: cd34 cd38; cord blood; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
The prognostic effect on childhood acute lymphoblastic leukemia of CD34+CD38− expressed in leukemia cells
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DOI: 10.1080/16078454.2022.2080368
Abstract: ABSTRACT Objective Acute lymphoblastic leukemia is the most common malignant disease in children. CD34 and CD38 are expressed in both normal and leukemia cells, but studies of their prognostic associations in childhood acute lymphoblastic leukemia… read more here.
Keywords: cd34; lymphoblastic leukemia; cd34 cd38; acute lymphoblastic ... See more keywords
Abstract B035: Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia
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DOI: 10.1158/1538-7445.canevol25-b035
Abstract: Cancer stem cells (CSCs), first identified in acute myeloid leukemia with a CD34+/CD38- phenotype, are hypothesized to sustain clonal survival through self-renewal and resistance to chemotherapy. In B-cell acute lymphoblastic leukemia (B-ALL), stem-like properties can… read more here.
Keywords: cd34 cd38; disease; stem like; stem ... See more keywords
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells
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DOI: 10.1182/blood-2018-99-120258
Abstract: Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow associated with poor clinical outcomes. Conventional chemotherapies are effective in debulking the leukemic burden in most AML patients. However, a small population of… read more here.
Keywords: cd34 cd38; expression; kpt 9274; activity ... See more keywords
Identification of an Expanded Immature Cell Population in Human Bone Marrow during Erythroid Responses to ESA Treatment
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DOI: 10.1182/blood-2019-130065
Abstract: Background and aim: Treatment with erythropoietin stimulating agents (ESA) is first-line treatment for anemic low-risk MDS patients, but although clinical variables such as endogenous serum erythropoietin levels have been associated with response, the bone marrow… read more here.
Keywords: cd34 cd38; treatment; esa treatment; mds patients ... See more keywords
Different Subsets of Haematopoietic Cells and Immune Cells in Bone Marrow between Young and Old Donors
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DOI: 10.1182/blood-2020-134758
Abstract: Background Young donors are reported to be associated with better transplant outcomes than old donors in allo-HSCT, but the underlying mechanism is still uncertain. Successful allo-HSCT relies on the rapid reconstitution of donor-derived haematopoietic and… read more here.
Keywords: cd34 cd38; frequency; cd45ra; old donors ... See more keywords
Flow MRD Monitoring Combining Laip/Dfn and CD34+CD38- LSCs Is a Strong Predictor of Outcome in Adult AML Independently of the ELN-2022 Risk: First Results from the Multicentric Acute Leukemia French Intergroup MRD Flow Network
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DOI: 10.1182/blood-2024-205457
Abstract: Introduction MRD monitoring is recommended for treatment response evaluation in clinical AML trials (ELN-2022 guidelines: Heuser et al, PMID 34724563). Besides molecular biology methods, multiparametric flow cytometry represents the most reliable approach. In this study,… read more here.
Keywords: cd34 cd38; laip dfn; eln 2022; dfn ... See more keywords
Searching for a myelodysplastic syndrome stem cells (MDS-SCs) signature by flow cytometry: Toward a new prognostic tool?
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DOI: 10.1182/blood-2025-5615
Abstract: Introduction Myelodysplastic Syndromes (MDS) are a group of clonal myeloid disorders characterized by poor prognosis and frequent progression to Acute Myeloid Leukemia (AML). Several studies focused on the properties of malignant stem cells that drive… read more here.
Keywords: cd34 cd38; group; mds; flow cytometry ... See more keywords
CD34+CD38−CD123+ Leukemic Stem Cell Frequency Predicts Outcome in Older Acute Myeloid Leukemia Patients Treated by Intensive Chemotherapy but Not Hypomethylating Agents
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DOI: 10.3390/cancers12051174
Abstract: The prognostic impact of immunophenotypic CD34+CD38−CD123+ leukemic stem cell (iLSC) frequency at diagnosis has been demonstrated in younger patients treated by intensive chemotherapy, however, this is less clear in older patients. Furthermore, the impact of… read more here.
Keywords: patients treated; cd34 cd38; frequency; intensive chemotherapy ... See more keywords