Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial
Sign Up to like & getrecommendations! Published in 2024 at "ESC Heart Failure"
DOI: 10.1002/ehf2.15124
Abstract: The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option… read more here.
Keywords: cd34 cells; trial; cd34; myocardial infarction ... See more keywords
Human primary CD34+ cells transplantation for critical limb ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22569
Abstract: The goal of this study was to characterize the properties of human CD34+ cells in culture and investigate the feasibility and efficacy of CD34+ transplantation in a mouse model of limb ischemia and in patients… read more here.
Keywords: limb; critical limb; limb ischemia; cd34 cells ... See more keywords
Experience in a Public Cord Blood Bank Using a Segment‐Based Aldehyde Dehydrogenase Assay as a Biomarker for Umbilical Cord Blood Potency
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS Translational Medicine"
DOI: 10.1002/sctm.12357
Abstract: Background: AMR-001, an autologous CD34+ cell product derived from mini-marrow harvest, is currently undergoing Phase II trials to treat acute myocardial infarction (AMI). At the time of AMR-001 infusion, it is believed that the infarct-region… read more here.
Keywords: mobilized cells; cord blood; cord; non mobilized ... See more keywords
Large‐Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.17-0057
Abstract: The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor cells has been considered as a potential method to overcome blood supply shortages. Here, we report that… read more here.
Keywords: medicine; cd34; vivo generation; generation human ... See more keywords
Design and Validation of an Automated Process for the Expansion of Peripheral Blood‐Derived CD34+ Cells for Clinical Use After Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.17-0277
Abstract: We previously demonstrated that intracardiac delivery of autologous peripheral blood‐derived CD34+ stem cells (SCs), mobilized by granulocyte‐colony stimulating factor (G‐CSF) and collected by leukapheresis after myocardial infarction, structurally and functionally repaired the damaged myocardial area.… read more here.
Keywords: medicine; cd34; expansion; blood ... See more keywords
Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function.
Sign Up to like & getrecommendations! Published in 2022 at "Cell and tissue research"
DOI: 10.1007/s00441-022-03592-2
Abstract: The use of CD34 + cell-based therapies has largely been focused on haematological conditions. However, there is increasing evidence that umbilical cord blood (UCB) CD34 + -derived cells have neuroregenerative properties. Due to low cell numbers of CD34 + cells present… read more here.
Keywords: umbilical cord; cd34 cells; cell; cord blood ... See more keywords
CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis
Sign Up to like & getrecommendations! Published in 2024 at "Cell and Tissue Research"
DOI: 10.1007/s00441-024-03892-9
Abstract: Synovial chondromatosis (SC) is a disorder of the synovium characterized by the formation of osteochondral nodules within the synovium. This study aimed to identify the abnormally differentiated progenitor cells and possible pathogenic signaling pathways. Loose… read more here.
Keywords: cd34 cells; synovial chondromatosis; cd34; cd34 synovial ... See more keywords
CD34+ and CD34− MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Hematology"
DOI: 10.1007/s12185-024-03867-0
Abstract: Despite the introduction of new drugs, multiple myeloma (MM) still remains incurable. We previously reported that CD34+ MM cells, which are clonogenic and self-renewing, are therapy-resistant and persist as a major component of minimal residual… read more here.
Keywords: cd137; cd34 cells; immune checkpoint; cd34 ... See more keywords
Cryopreserved Cd34 Cells: Measuring Viability Pre-Thaw and Viability over Time Post-Thaw
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.310
Abstract: Common practices associated with the use of cryopreserved hematopoietic progenitor cells (HPC) include measuring the viability of the thawed cells from a sample derived from the thawed product, and thawing cells at the patient's bedside… read more here.
Keywords: viability; cd34 cells; post thaw;
Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.12.006
Abstract: We describe the establishment of an embryoid-body-based protocol for hematopoietic/myeloid differentiation of human induced pluripotent stem cells that allows the generation of CD34+ cells or mature myeloid cells in vitro. Using this model, we were… read more here.
Keywords: dna damage; congenital neutropenia; cd34 cells; severe congenital ... See more keywords
Non-Pulsatile Flow is Associated with Lower Levels of Circulating CD34+ Cells in LVAD-Supported Patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.543
Abstract: Purpose The lack of pulsatility may be associated with altered angiogensis in LVAD patients. Since CD34+ cells represent an important regulator of angiogenesis in heart failure, we sought to investigate a potential correlation between flow… read more here.
Keywords: cd34 cells; cell; pulsatile flow; cd34 ... See more keywords