Human primary CD34+ cells transplantation for critical limb ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22569
Abstract: The goal of this study was to characterize the properties of human CD34+ cells in culture and investigate the feasibility and efficacy of CD34+ transplantation in a mouse model of limb ischemia and in patients… read more here.
Keywords: limb; critical limb; limb ischemia; cd34 cells ... See more keywords
Experience in a Public Cord Blood Bank Using a Segment‐Based Aldehyde Dehydrogenase Assay as a Biomarker for Umbilical Cord Blood Potency
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS Translational Medicine"
DOI: 10.1002/sctm.12357
Abstract: Background: AMR-001, an autologous CD34+ cell product derived from mini-marrow harvest, is currently undergoing Phase II trials to treat acute myocardial infarction (AMI). At the time of AMR-001 infusion, it is believed that the infarct-region… read more here.
Keywords: mobilized cells; cord blood; cord; non mobilized ... See more keywords
Large‐Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.17-0057
Abstract: The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor cells has been considered as a potential method to overcome blood supply shortages. Here, we report that… read more here.
Keywords: medicine; cd34; vivo generation; generation human ... See more keywords
Design and Validation of an Automated Process for the Expansion of Peripheral Blood‐Derived CD34+ Cells for Clinical Use After Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.17-0277
Abstract: We previously demonstrated that intracardiac delivery of autologous peripheral blood‐derived CD34+ stem cells (SCs), mobilized by granulocyte‐colony stimulating factor (G‐CSF) and collected by leukapheresis after myocardial infarction, structurally and functionally repaired the damaged myocardial area.… read more here.
Keywords: medicine; cd34; expansion; blood ... See more keywords
Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function.
Sign Up to like & getrecommendations! Published in 2022 at "Cell and tissue research"
DOI: 10.1007/s00441-022-03592-2
Abstract: The use of CD34 + cell-based therapies has largely been focused on haematological conditions. However, there is increasing evidence that umbilical cord blood (UCB) CD34 + -derived cells have neuroregenerative properties. Due to low cell numbers of CD34 + cells present… read more here.
Keywords: umbilical cord; cd34 cells; cell; cord blood ... See more keywords
Cryopreserved Cd34 Cells: Measuring Viability Pre-Thaw and Viability over Time Post-Thaw
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.310
Abstract: Common practices associated with the use of cryopreserved hematopoietic progenitor cells (HPC) include measuring the viability of the thawed cells from a sample derived from the thawed product, and thawing cells at the patient's bedside… read more here.
Keywords: viability; cd34 cells; post thaw;
Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.12.006
Abstract: We describe the establishment of an embryoid-body-based protocol for hematopoietic/myeloid differentiation of human induced pluripotent stem cells that allows the generation of CD34+ cells or mature myeloid cells in vitro. Using this model, we were… read more here.
Keywords: dna damage; congenital neutropenia; cd34 cells; severe congenital ... See more keywords
Non-Pulsatile Flow is Associated with Lower Levels of Circulating CD34+ Cells in LVAD-Supported Patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.543
Abstract: Purpose The lack of pulsatility may be associated with altered angiogensis in LVAD patients. Since CD34+ cells represent an important regulator of angiogenesis in heart failure, we sought to investigate a potential correlation between flow… read more here.
Keywords: cd34 cells; cell; pulsatile flow; cd34 ... See more keywords
Phenotypic characterization of malignant progenitor cells in patients with idiopathic myelofibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2019.01.001
Abstract: OBJECTIVE/BACKGROUND Idiopathic myelofibrosis (IM) is a clonal hematological malignancy originating from pluripotent hematopoietic stem cells (HSC). HSC are very rare potent cells that reside in the bone marrow (BM) and at a lower level in… read more here.
Keywords: cd34; progenitor cells; idiopathic myelofibrosis; malignant progenitor ... See more keywords
A Study of novel mechanism of hypoxic preconditioned CD34+cells improving therapeutic efficacy for critical limb ischemia: role of exosomal miRNA-378a-5p
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.070
Abstract: Background & Aim CD34+cells transplantation has shown therapeutic angiogenesis efficacy in treating critical limb ischemia. Hypoxic preconditioning can increase the proangiogenic ability. As the main component of the paracrine secretion of CD34+ cells, CD34+ cell… read more here.
Keywords: cd34 cells; efficacy; limb ischemia; preconditioned cd34 ... See more keywords
Transcriptome analysis of CD34+ cells from myelodysplastic syndrome patients.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.09.003
Abstract: The myelodysplastic syndrome (MDS) represents a heterogeneous group of clonal hematologic stem cell disorders with the characteristic of ineffective hematopoiesis leading to low blood counts, and a risk of progression to acute myeloid leukemia (AML).… read more here.
Keywords: analysis; refractory anemia; mds subtypes; myelodysplastic syndrome ... See more keywords