An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.07.019
Abstract: Innate lymphoid cells (ILCs) are critical effectors of innate immunity and inflammation, whose development and activation pathways make for attractive therapeutic targets. However, human ILC generation has not been systematically explored, and previous in vitro investigations… read more here.
Keywords: innate lymphoid; hematopoietic progenitors; lymphoid cells; cd34 hematopoietic ... See more keywords
A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2019.112703
Abstract: Dendritic cells (DCs) play a central role in regulating innate and adaptive immune responses. It is well accepted that their regulatory functions change over the life course. In order to study DCs function during early… read more here.
Keywords: cd34 hematopoietic; neonatal dcs; cord blood; dcs ... See more keywords
A novel method to evaluate prethawing viability of cryopreserved CD34+ hematopoietic stem cells for autologous transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Transfusion"
DOI: 10.1111/trf.15825
Abstract: Cryopreservation of CD34+ hematopoietic stem cells (HSCs) is associated with variable loss of viability. Although postfreezing CD34+ cell viability can be assessed on the sampling tube (bag tail) directly connected to the main bag (mother… read more here.
Keywords: novel method; viability; hematopoietic stem; cd34 hematopoietic ... See more keywords
miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23572
Abstract: Tip110 expression regulates hematopoiesis, but the regulatory mechanisms during hematopoiesis are not fully understood. There are a number of putative microRNA (miRNA) binding sites identified within the Tip110 3′ untranslated region (3′UTR). In this study,… read more here.
Keywords: human cd34; tip110; expression; cd34 hematopoietic ... See more keywords