Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301377
Abstract: Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable.… read more here.
Keywords: lipid nanoparticles; bone marrow; cd38; rna ... See more keywords
Better resolving of anti-CD38 antibody interference with blood compatibility testing by using manual polybrene method compared with dithiothreitol-pretreatment indirect antiglobulin test.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24891
Abstract: BACKGROUND It is advised to pretreat the reagent erythrocytes with Dithiothreitol (DTT) to denature the surface CD38 to prevent anti-CD38 monoclonal antibodies (MoAb) from interfering with the blood compatibility test. Anti-CD38 has little impact on… read more here.
Keywords: anti cd38; polybrene; dtt iat; cd38 ... See more keywords
The multi-faceted potential of CD38 antibody targeting in multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-1990-2
Abstract: CD38, an adenine dinucleotide phosphate (ADP) ribose cyclase and a cyclic ADP ribose hydrolase, is widely expressed on the surface of multiple myeloma (MM) cells. It is known to play a pivotal role in the… read more here.
Keywords: cd38 moabs; antibody; cd38; multi faceted ... See more keywords
Inhibiting the CD38/cADPR pathway protected rats against sepsis associated brain injury
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.09.029
Abstract: BACKGROUND The CD38/cADPR pathway has been found to play roles in various inflammatory conditions. However, whether CD38 plays a protective or detrimental effect in the central nervous system (CNS) is controversial. The aim of this… read more here.
Keywords: clp; cadpr pathway; cd38 cadpr; cadpr ... See more keywords
Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.10.014
Abstract: The CD38, possessing ADP-ribosyl cyclase (ADPR-cyclase) and cyclic ADP-ribose hydrolase (cADPR-hydrolase), is able to regulate a variety of cellular activities. However, the role and mechanisms for CD38 in macrophage activation and sepsis-induced acute kidney injury… read more here.
Keywords: kidney injury; cd38; acute kidney; induced macrophage ... See more keywords
Enhancing proteasome‐inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.11.045
Abstract: Abstract The establishment of more effective treatments that can circumvent chemoresistance in Multiple Myeloma (MM) is a priority. Although bortezomib (BTZ) is one of the most potent proteasome inhibitors available, still possesses limitations related to… read more here.
Keywords: cd38; multiple myeloma; proteasome inhibitory; cd38 targeted ... See more keywords
CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.12.050
Abstract: Morphological screening of mouse brains with known behavioral deficits can give great insight into the relationship between brain regions and their behavior. Oxytocin- and CD38-deficient mice have previously been shown to have behavioral phenotypes, such… read more here.
Keywords: cortex; cortex hippocampus; pathology; cd38 ... See more keywords
DaraEx® : Le graal de la transfusion ?
Sign Up to like & getrecommendations! Published in 2019 at "Transfusion Clinique et Biologique"
DOI: 10.1016/j.tracli.2019.06.079
Abstract: Introduction Le daratumumab (dara), anticorps monoclonal ciblant le CD38 utilise dans le traitement du myelome multiple, interfere avec les tests pre-transfusionnels realises en methode indirecte a l’antiglobuline (TIA) generant des reactions faussement positives pouvant masquer un… read more here.
Keywords: transfusion; cd38; daraex; allo anticorps ... See more keywords
HDAC inhibitor suppresses proliferation and tumorigenicity of drug‐resistant chronic myeloid leukemia stem cells through regulation of hsa‐miR‐196a targeting BCR/ABL1
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.07.017
Abstract: &NA; Failure to eradicate hematologic cancer stem cells (hCSCs) associated with resistance to tyrosine kinase inhibitors such as imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is a clinical challenge that highlights the need… read more here.
Keywords: cd34 cd38; hsa mir; mir 196a; cd38 ... See more keywords
Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine induced ventricular arrhythmias.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2022.01.008
Abstract: CD38 enzymatic activity regulates NAD+ and cADPR levels in mammalian tissues, and therefore has a prominent role in cellular metabolism and calcium homeostasis. Consequently, it is reasonable to hypothesize about its involvement in cardiovascular physiology… read more here.
Keywords: exercise capacity; mice; heart; heart rate ... See more keywords
Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00688
Abstract: CD38 is one of the major nicotinamide adenine dinucleotide (NAD+)- and nicotinamide adenine dinucleotide phosphate (NADP+)-consuming enzymes in mammals. NAD+, NADP+, and their reduced counterparts are essential coenzymes for numerous enzymatic reactions, including the maintenance… read more here.
Keywords: enzymatic inhibitor; cd38; inhibitor; heart ... See more keywords