2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100300
Abstract: The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro-pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)-activated P2Y12 receptors on thrombocytes. In their native, nonmetabolized form, both drugs… read more here.
Keywords: allosteric ectonucleotidase; derivatives allosteric; substituted thienotetrahydropyridine; ectonucleotidase inhibitors ... See more keywords
The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174729
Abstract: Alcoholic liver disease caused by chronic excessive drinking has become one of the most common types of liver disease. Alcohol-induced inflammatory immune responses play a central role in the development of alcohol-associated steatohepatitis. The content… read more here.
Keywords: expression; cd39; p2x4; atp ... See more keywords
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
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DOI: 10.1038/s41467-025-56093-5
Abstract: Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain. Here, we show that microglia regulate the cerebral blood flow baseline and the responses to whisker… read more here.
Keywords: blood flow; cerebral blood; cd39; adenosine ... See more keywords
Flow cytometric expression of CD71, CD81, CD44 and CD39 in B cell lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2021.1929446
Abstract: Abstract Flow cytometry is a useful ancillary tool for the diagnosis of nodal B cell lymphomas. Well-established antigens have diagnostic limitations. This study aimed to assess the expression of CD71, CD81, CD44 and CD39 by… read more here.
Keywords: cd81; cell lymphoma; cd71; expression ... See more keywords
Expression of the Transcription Factor FOXP3 in Human Peripheral Blood B-Cell Subtypes (CD19+CD39+ and CD19+CD39-) and Evaluation of Their Regulatory Function
Sign Up to like & getrecommendations! Published in 2025 at "Immunological Investigations"
DOI: 10.1080/08820139.2025.2515411
Abstract: ABSTRACT Introduction The aim of this study was to evaluate FOXP3 expression in CD19+CD39+ and CD19+CD39− B cells, and to investigate its potential regulatory role. Methods Peripheral B cells were obtained from 25 volunteers. FOXP3… read more here.
Keywords: cd39; cd19 cd39; cd39 cd19; cd39 cells ... See more keywords
A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2018 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehx218
Abstract: Aims CD39 is a cell membrane NTPase with anti-inflammatory and anti-platelet effects. However, its clinical use is limited by its bleeding side effect. With the goal of harnessing its therapeutic potential while avoiding haemostatic problems,… read more here.
Keywords: targ cd39; activated platelets; fusion protein; single chain ... See more keywords
Mechanisms of Sepsis from a Metabolic Immunology Perspective: A Bidirectional Mendelian Randomization and Single-Cell Sequencing Study of CD39+ Cells.
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DOI: 10.1097/shk.0000000000002633
Abstract: BACKGROUND Interactions between immune phenotypes and metabolites in sepsis pathogenesis remain poorly defined. We integrated Mendelian randomization (MR) and single-cell transcriptomics to investigate metabolic mediation in immune-sepsis associations. METHODS Bidirectional two-sample MR analyzed sepsis GWAS… read more here.
Keywords: immunology; cd39; single cell; mendelian randomization ... See more keywords
Disruption of the ATP/adenosine balance in CD39−/− mice is associated with handling‐induced seizures
Sign Up to like & getrecommendations! Published in 2017 at "Immunology"
DOI: 10.1111/imm.12798
Abstract: Seizures are due to excessive, synchronous neuronal firing in the brain and are characteristic of epilepsy, the fourth most prevalent neurological disease. We report handling‐induced and spontaneous seizures in mice deficient for CD39, a cell‐surface… read more here.
Keywords: cd39 mice; induced seizures; handling induced; atp adenosine ... See more keywords
Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Immunology"
DOI: 10.1111/imm.13832
Abstract: The adverse effects observed in some cancer patients treated with erythropoiesis‐stimulating agents such as erythropoietin (EPO) might be due to the latter's well‐known immunosuppressive functions. Here, we used a mouse model of syngeneic triple‐negative breast… read more here.
Keywords: cancer; cd39; tumour progression; negative breast ... See more keywords
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-214877
Abstract: Objectives We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness… read more here.
Keywords: loci; response; association; response tnf ... See more keywords
AB0027 INCREASED CIRCULATING CD39+FOXP3+CD4+ TREG CELLS IN EARLY RHEUMATOID ARTHRITIS FACILITATE THE ANTIINFLAMMATORY ACTION OF METHOTREXATE
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.2680
Abstract: Methotrexate (MTX) remains the first line of treatment in Rheumatoid Arthritis (RA)1,2. Inhibition of AICAR transformylase by MTX results in augmented release of adenine nucleotides to the extracellular space1; these are rapidly hydrolysed by the… read more here.
Keywords: era; mtx; none declared; treg ... See more keywords