2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors.
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DOI: 10.1002/ardp.202100300
Abstract: The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro-pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)-activated P2Y12 receptors on thrombocytes. In their native, nonmetabolized form, both drugs… read more here.
Keywords: allosteric ectonucleotidase; derivatives allosteric; substituted thienotetrahydropyridine; ectonucleotidase inhibitors ... See more keywords
The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174729
Abstract: Alcoholic liver disease caused by chronic excessive drinking has become one of the most common types of liver disease. Alcohol-induced inflammatory immune responses play a central role in the development of alcohol-associated steatohepatitis. The content… read more here.
Keywords: expression; cd39; p2x4; atp ... See more keywords
Flow cytometric expression of CD71, CD81, CD44 and CD39 in B cell lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2021.1929446
Abstract: Abstract Flow cytometry is a useful ancillary tool for the diagnosis of nodal B cell lymphomas. Well-established antigens have diagnostic limitations. This study aimed to assess the expression of CD71, CD81, CD44 and CD39 by… read more here.
Keywords: cd81; cell lymphoma; cd71; expression ... See more keywords
A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury
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DOI: 10.1093/eurheartj/ehx218
Abstract: Aims CD39 is a cell membrane NTPase with anti-inflammatory and anti-platelet effects. However, its clinical use is limited by its bleeding side effect. With the goal of harnessing its therapeutic potential while avoiding haemostatic problems,… read more here.
Keywords: targ cd39; activated platelets; fusion protein; single chain ... See more keywords
Disruption of the ATP/adenosine balance in CD39−/− mice is associated with handling‐induced seizures
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DOI: 10.1111/imm.12798
Abstract: Seizures are due to excessive, synchronous neuronal firing in the brain and are characteristic of epilepsy, the fourth most prevalent neurological disease. We report handling‐induced and spontaneous seizures in mice deficient for CD39, a cell‐surface… read more here.
Keywords: cd39 mice; induced seizures; handling induced; atp adenosine ... See more keywords
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-214877
Abstract: Objectives We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness… read more here.
Keywords: loci; response; association; response tnf ... See more keywords
AB0027 INCREASED CIRCULATING CD39+FOXP3+CD4+ TREG CELLS IN EARLY RHEUMATOID ARTHRITIS FACILITATE THE ANTIINFLAMMATORY ACTION OF METHOTREXATE
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DOI: 10.1136/annrheumdis-2021-eular.2680
Abstract: Methotrexate (MTX) remains the first line of treatment in Rheumatoid Arthritis (RA)1,2. Inhibition of AICAR transformylase by MTX results in augmented release of adenine nucleotides to the extracellular space1; these are rapidly hydrolysed by the… read more here.
Keywords: era; mtx; none declared; treg ... See more keywords
On the mechanism of anti-CD39 immune checkpoint therapy
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DOI: 10.1136/jitc-2019-000186
Abstract: With the coming of age of cancer immunotherapy, the search for new therapeutic targets has led to the identification of immunosuppressive adenosine as an important regulator of antitumor immunity. This resulted in the development of… read more here.
Keywords: anti cd39; mechanism anti; therapy; cd39 immune ... See more keywords
Abstract 2640: Small-molecule inhibitors of CD73, CD39 and A2aR: Three anti-cancer targets in the ATP/adenosine signaling pathway
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DOI: 10.1158/1538-7445.am2017-2640
Abstract: INTRODUCTION: In the tumor micro-environment (TME) Adenosine (ADO) dampens the immune response towards cancer cells by inhibiting the cytotoxic activity of effector cells and promoting the proliferation of immunosuppressive cells. Extracellular ADO is generated by… read more here.
Keywords: tumor; ado; small molecule; inhibition ... See more keywords
Abstract 4984: Where do the T lymphocytes go in prostate cancer: Correlation with CD103, CD39 expression and clinical pathological parameters
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DOI: 10.1158/1538-7445.am2020-4984
Abstract: Introduction: Many solid tumors such as prostate cancer have shown limited response to immunotherapy treatment. Whether this is due to absence of tumor specific antigens or poor immune infiltrate, the exact mechanism is not well… read more here.
Keywords: cd4 cd8; cd103; prostate cancer; cd39 ... See more keywords
Abstract 4645: Identification of conditionally active antibodies that selectively block CD39 activity in the acidic tumor microenvironment
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DOI: 10.1158/1538-7445.am2023-4645
Abstract: Background CD39 expression is upregulated in the tumor microenvironment (TME), which is characterized by high levels of extracellular ATP (eATP) and low pH. CD39 catalyzes the rate-limiting degradation step of this immunostimulatory ATP, leading to… read more here.
Keywords: cd39; inhibition; cd39 activity; activity ... See more keywords