Assessment of CD39 expression in regulatory T‐cell subsets by disease severity in adult and juvenile COVID‐19 cases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27593
Abstract: COVID‐19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID‐19 immunopathogenesis and its… read more here.
Keywords: covid; cd39 expression; severity; cell subsets ... See more keywords
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.01.004
Abstract: Rheumatoid arthritis (RA) is an autoimmune arthropathy characterized by chronic articular inflammation. Methotrexate (MTX) remains the first-line therapy for RA and its anti-inflammatory effect is associated with the maintenance of high levels of extracellular adenosine… read more here.
Keywords: cd39 expression; tgf; resistance; expression ... See more keywords
CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells-Response.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0950
Abstract: We are pleased to know that our work has inspired Thelen and colleagues ([1][1]) to study CD39+CD8+ T cells in other human tumor entities. In accordance with our observations in patients with breast cancer ([2][2]),… read more here.
Keywords: cd8 cells; cd39 expression; defines cell; expression defines ... See more keywords
IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression
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DOI: 10.1172/jci.insight.157509
Abstract: The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development and contributes to T cell exhaustion, thereby… read more here.
Keywords: cell; adenosine mediated; expression; prevents adenosine ... See more keywords