Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
Sign Up to like & getrecommendations! Published in 2022 at "Structure"
DOI: 10.1016/j.str.2022.03.012
Abstract: Nanobodies can achieve remarkable neutralization of genetically diverse pathogens, including HIV-1. To gain insight into their recognition, we determined crystal structures of four llama nanobodies (J3, A12, C8, and D7), all of which targeted the… read more here.
Keywords: cd4 binding; site; neutralization; binding site ... See more keywords
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.03.16.484662
Abstract: The induction of broadly neutralizing antibodies (bNAbs) is a potential strategy for a vaccine against HIV-1. However, most bNAbs exhibit features such as unusually high somatic hypermutation, including insertions and deletions, which make their induction… read more here.
Keywords: class; induction; cd4 binding; binding site ... See more keywords
Design of human immunodeficiency virus-1 neutralizing peptides targeting CD4-binding site: An integrative computational biologics approach
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1036874
Abstract: Peptide therapeutics have recently gained momentum in antiviral therapy due to their increased potency and cost-effectiveness. Interaction of the HIV-1 envelope gp120 with the host CD4 receptor is a critical step for viral entry, and… read more here.
Keywords: cd4; design; cd4 binding; gp120 ... See more keywords
Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020474
Abstract: Broadly neutralizing antibodies (bNAbs) are potent in neutralizing a wide range of HIV strains. VRC01 is a CD4-binding-site (CD4-bs) class of bNAbs that binds to the conserved CD4-binding region of HIV-1 envelope (env) protein. Natural… read more here.
Keywords: hiv; entry; hiv entry; clade ... See more keywords