Endogenous IFN‐γ facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4+ T cell‐depleted mice
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DOI: 10.1002/1873-3468.14875
Abstract: IFN‐γ plays a critical role in host defense against intracellular pathogens. IFN‐γ is produced in the bronchoalveolar lavage fluid of mice infected with Pneumocystis, but the role of IFN‐γ in host defense against Pneumocystis remains… read more here.
Keywords: cd4 cell; cell depleted; endogenous ifn; facilitates pneumocystis ... See more keywords
Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice *
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747091
Abstract: The ability of different CD4+ T cell subsets to help CD8+ T‐cell response is not fully understood. Here, we found using the murine system that Th17 cells induced by IL‐1β, unlike Th1, were not effective… read more here.
Keywords: deviation; cd8; response; cd4 cell ... See more keywords
Northern pig‐tailed macaques (Macaca leonina) maintain superior CD4+ T‐cell homeostasis during SIVmac239 infection
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747284
Abstract: Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. read more here.
Keywords: northern pig; infection; cell homeostasis; cd4 cell ... See more keywords
Distinct Requirements for CD4+ T Cell Help for Immune Responses Induced by mRNA and Adenovirus‐Vector SARS‐CoV‐2 Vaccines
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202451142
Abstract: CD4+ T cells have been established as central orchestrators of cellular and humoral immune responses to infection or vaccination. However, the need for CD4+ T cell help to generate primary CD8+ T cell responses is… read more here.
Keywords: cd4 cell; cell; cell help; vaccine ... See more keywords
Interplay of Vitamin D and Aryl Hydrocarbon Receptors in CD4+ T Cell Fate Determination
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DOI: 10.1002/jbt.70360
Abstract: It seems that vitamin D receptor (VDR) and aryl hydrocarbon receptor (AHR) are important receptors that determine the fate of CD4+ T cell differentiations under various physiological and pathophysiological conditions. Herein, we aim to investigate the… read more here.
Keywords: cd4 cell; cell; vitamin; aryl hydrocarbon ... See more keywords
Dectin‐1 signaling in neutrophils up‐regulates PD‐L1 and triggers ROS‐mediated suppression of CD4+ T cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0322-152rr
Abstract: Dectin‐1 is known to drive proinflammatory cytokine production by macrophages and dendritic cells which promotes Th17 CD4+ T cell responses in the setting of fungal infection. However, the role of Dectin‐1 signaling in neutrophils and… read more here.
Keywords: dectin signaling; cd4 cells; cd4; signaling neutrophils ... See more keywords
Suboptimal immune recovery and associated factors among people living with HIV/AIDS on second‐line antiretroviral therapy in central China: A retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27944
Abstract: The introduction and scale‐up of antiretroviral therapy (ART) have contributed to significantly improved patients with acquired immune deficiency syndrome (AIDS) quality of life and prolongs their survival. This has occurred by suppressing viral replication and… read more here.
Keywords: cell count; line art; cd4 cell; line ... See more keywords
Interleukin‐2‐mediated CD4 T‐cell activation correlates highly with effective serological and T‐cell responses to SARS‐CoV‐2 vaccination in people living with HIV
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29820
Abstract: People living with HIV (PLWH) despite having an appreciable depletion of CD4+ T‐cells show a good severe acute respiratory syndrome coronavirus 2 vaccination response. The underlying mechanism(s) are currently not understood. We studied serological and… read more here.
Keywords: cd4 cell; activation; cell; vaccination ... See more keywords
Epidemiological Trends and CD4+T Cell Recovery in HIV‐1 Patients With HCV/HBV Co‐Infection: A Retrospective Cohort Study in Southwest China (2003–2024)
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70465
Abstract: Co‐infection with HIV and chronic viral hepatitis (HBV and HCV) contributes to increased morbidity and complicates treatment outcomes. However, in Southwest China, a high‐burden region epidemiological data on HIV/HBV and HIV/HCV co‐infection remain limited. We… read more here.
Keywords: cd4 cell; hiv; recovery; infection ... See more keywords
Environmental peer pressure: CD4+ T cell help in tolerance and transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Liver Transplantation"
DOI: 10.1002/lt.24873
Abstract: The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic‐rich intestinal blood, oxidative stress, and metabolic intermediates, there is no appreciable immune response. Interestingly,… read more here.
Keywords: cell help; cd4 cell; transplantation; cd4 ... See more keywords
Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2019_405
Abstract: Pertussis remains endemic in vaccinated populations due to waning of vaccine-induced immunity and insufficient interruption of transmission. Correlates of long-term protection against whooping cough remain elusive but increasing evidence from experimental models indicates that the… read more here.
Keywords: immunity; infection; specific cd4; cd4 cell ... See more keywords