Phenotype‐Based Isolation of Antigen‐Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104766
Abstract: The pathogenic immune response in celiac disease (CeD) is orchestrated by phenotypically distinct CD4+ T cells that recognize gluten epitopes in the context of disease‐associated HLA‐DQ allotypes. Cells with the same distinct phenotype, but with… read more here.
Keywords: cd4 cells; disease; ttet tphe; tphe ... See more keywords
FOXP1 is a regulator of quiescence in healthy human CD4+ T cells and is constitutively repressed in T cells from patients with lymphoproliferative disorders
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646373
Abstract: The forkhead box P1 (FOXP1) transcription factor has been shown to regulate the generation and maintenance of quiescent naïve murine T cells. In humans, FOXP1 expression has been correlated with overall survival in patients with… read more here.
Keywords: cd4 cells; human cd4; patients lymphoproliferative; lymphoproliferative disorders ... See more keywords
BJ‐2266 ameliorates experimental autoimmune encephalomyelitis through down‐regulation of the JAK/STAT signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646860
Abstract: CD4+ T cells differentiate into distinct effector subsets upon antigenic stimulation. Cytokines, and micro‐environmental factors present during T‐cell priming, direct differentiation of naïve CD4+ T cells into pro‐inflammatory Th1 and Th17 cells. From extensive screening… read more here.
Keywords: cd4 cells; jak stat; differentiation; autoimmune encephalomyelitis ... See more keywords
Inhibition of endoplasmic reticulum stress and the downstream pathways protects CD4+ T cells against apoptosis and immune dysregulation in sepsis
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2666
Abstract: Immunosuppression mediated by CD4+ T cell apoptosis and dysfunction is a key factor in promoting the progression of sepsis. Endoplasmic reticulum (ER) stress participates in the apoptosis and dysfunction of immune cells. We aimed to… read more here.
Keywords: sepsis; endoplasmic reticulum; stress; apoptosis ... See more keywords
The role of Th9 CD4 + T cells and IL‐9 during primary Sjogren's syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24646
Abstract: The objective of this study is to investigate the expression levels of Th9 CD4+ T cells and IL‐9 secretion in peripheral blood mononuclear cells of patients with primary Sjogren's syndrome. Further, this study aimed to… read more here.
Keywords: th9 cd4; cd4 cells; role th9; sjogren syndrome ... See more keywords
IL‐26 promotes the pathogenesis of malignant pleural effusion by enhancing CD4+IL‐22+ T‐cell differentiation and inhibiting CD8+ T‐cell cytotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0221-479rr
Abstract: IL‐26 is a newly discovered IL‐10 cytokine family member mainly secreted by Th17 cells. However, the relationship between IL‐26 and lung cancer remains unclear. The present study reported that IL‐26 is involved in the production… read more here.
Keywords: mpe; cd4 cells; cd4; pleural effusion ... See more keywords
Dectin‐1 signaling in neutrophils up‐regulates PD‐L1 and triggers ROS‐mediated suppression of CD4+ T cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0322-152rr
Abstract: Dectin‐1 is known to drive proinflammatory cytokine production by macrophages and dendritic cells which promotes Th17 CD4+ T cell responses in the setting of fungal infection. However, the role of Dectin‐1 signaling in neutrophils and… read more here.
Keywords: dectin signaling; cd4 cells; cd4; signaling neutrophils ... See more keywords
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ri0220-603rr
Abstract: The goal of precision immunotherapy is to direct a patient's T cell response against the immunogenic mutations expressed on their tumors. Most immunotherapy approaches to‐date have focused on MHC class I‐restricted peptide epitopes by which… read more here.
Keywords: cd4 cells; immunotherapy; cells cancer; cancer immunotherapy ... See more keywords
Nanosome-Mediated Delivery Of Hdac Inhibitors and Oxygen Molecules for the Transcriptional Reactivation of Latent Hiv-Infected Cd4+ T Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301730
Abstract: The treatment of human immunodeficiency virus (HIV) infection is notoriously difficult due to the ability of this virus to remain latent in the host's CD4+ T cells. Histone deacetylases (HDACs) interfere with DNA transcription in… read more here.
Keywords: cd4 cells; hdac inhibitors; hiv infected; drug ... See more keywords
Blimp1 suppressed CD4+ T cells‐induced activation of fibroblast‐like synoviocytes by upregulating IL‐10 via the rho pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23672
Abstract: B lymphocyte‐induced maturation protein 1 (Blimp1) is a risk allele for rheumatoid arthritis (RA), but its functional mechanism in RA remains to be further explored. read more here.
Keywords: cd4 cells; suppressed cd4; activation fibroblast; cells induced ... See more keywords
A Method to In Vitro Differentiate Th9 Cells from Mouse Naïve CD4+ T Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6877-0_4
Abstract: CD4+ T helper cells with the ability to produce effector cytokines provide host protection by regulating immune responses against pathogens. In contrast, these cells are responsible for the development of various inflammatory disease if not… read more here.
Keywords: cd4 cells; th9 cells; differentiate; th9 ... See more keywords