When Helpers Go Above and Beyond: Development and Characterization of Cytotoxic CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.951900
Abstract: Once regarded as an experimental artefact, cytotoxic CD4+ T cells (CD4 CTL) are presently recognized as a biologically relevant T cell subset with important functions in anti-viral, anti-tumor, and autoimmune responses. Despite the potentially large… read more here.
Keywords: cd4 cells; cytotoxic cd4; cd4 ctl; cd4 ... See more keywords
CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1168125
Abstract: CD4+ T cells are typically considered as ‘helper’ or ‘regulatory’ populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity and CD4+ cytotoxic T cells… read more here.
Keywords: cd4; cd4 cell; cd4 ctl; memory ... See more keywords
Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of immunology"
DOI: 10.4049/jimmunol.2300748
Abstract: In contrast to the "helper" activities of most CD4+ T effector subsets, CD4+ cytotoxic T lymphocytes (CD4-CTLs) perform functions normally associated with CD8+ T and NK cells. Specifically, CD4-CTLs secrete cytotoxic molecules and directly target… read more here.
Keywords: cd4 cells; eos aiolos; cd4 ctl; cytotoxic programming ... See more keywords