Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Statins) Suppress Proliferation and Motility of Human CD4+ T Lymphocytes in Culture.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05350-w
Abstract: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) along with their blood lipid-lowering effect exhibit anti-inflammatory and immunomodulatory activity. We studied the effects of long-term (72-h or longer) exposure of human T lymphocytes in culture to atorvastatin… read more here.
Keywords: cd4; methylglutaryl coenzyme; hydroxy methylglutaryl; lymphocytes culture ... See more keywords
Correlation and clinical significance of LC3, CD68+ microglia, CD4+ T lymphocytes, and CD8+ T lymphocytes in gliomas
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2018.02.044
Abstract: OBJECTIVE To investigate the relationship between the expression of microtubule-associated protein LC3 and the numbers of CD68 + microglia, CD4 + T lymphocytes and CD8 + T lymphocytes, as well as the clinical significance of those factors in gliomas. PATIENTS AND… read more here.
Keywords: cd8 lymphocytes; cd4 lymphocytes; microglia cd4; cd68 microglia ... See more keywords
Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2016.12.015
Abstract: The membrane protein expression repertoire of cells changes in course of activation. In equine recurrent uveitis (ERU), a spontaneous autoimmune disease in horses with relapsing and ultimately blinding inner eye inflammation, CD4+ T lymphocytes are… read more here.
Keywords: medicine; cd4; cd4 cells; formin like ... See more keywords
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
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DOI: 10.1038/s41467-020-17136-1
Abstract: CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4+ T cells are… read more here.
Keywords: cd4; bethigh memory; memory phenotype; differentiation ... See more keywords
Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45260-6
Abstract: Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that… read more here.
Keywords: cd4 lymphocytes; tcr cd3; mediated activation; cd3 mediated ... See more keywords
Estradiol-induced inhibition of endoplasmic reticulum stress normalizes splenic CD4 + T lymphocytes following hemorrhagic shock
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87159-1
Abstract: The aim is to investigate that 17β-estradiol (E2)/estrogen receptors (ERs) activation normalizes splenic CD4 + T lymphocytes proliferation and cytokine production through inhibition of endoplasmic reticulum stress (ERS) following hemorrhage. The results showed that hemorrhagic shock (hemorrhage… read more here.
Keywords: splenic cd4; hemorrhagic shock; cd4 lymphocytes; normalizes splenic ... See more keywords
Assay and Isolation of Single Proliferating CD4+ Lymphocytes Using an Automated Microraft Array Platform
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2019.2956081
Abstract: Objective: While T lymphocytes have been employed as a cancer immunotherapy, the development of effective and specific T-cell-based therapeutics remains challenging. A key obstacle is the difficulty in identifying T cells reactive to cancer-associated antigens.… read more here.
Keywords: array; platform; cell; isolation ... See more keywords
P169 Association between CXCR4 and TRAIL pathway expression in CD4 T lymphocytes from HIV+ ART-naïve patients
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.328
Abstract: Background HIV infection is characterized by immune cells depletion, apoptosis is one of the main mechanisms described. It has been reported that, the union of HIV to coreceptor CXCR4 can induce Fas independent apoptosis on… read more here.
Keywords: lymphocytes hiv; trail; expression; cd4 lymphocytes ... See more keywords
Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes
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DOI: 10.1159/000495241
Abstract: Background/Aims: Immunosuppression frequently occurs during the development of sepsis and is closely associated with poor outcome. Characteristics of immunosuppressive CD4+ T lymphocytes in sepsis have been reported to include dramatic cell loss and inactivation. p53… read more here.
Keywords: cd4; sepsis; p53; cell ... See more keywords
Replication competence of virions induced from CD4+ lymphocytes latently infected with HIV
Sign Up to like & getrecommendations! Published in 2019 at "Retrovirology"
DOI: 10.1186/s12977-019-0466-1
Abstract: Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir has been quantified with the terminal dilution quantitative viral outgrowth assay, which induces… read more here.
Keywords: cd4 lymphocytes; hiv; replication competence; replication competent ... See more keywords
Long-Term Effects of Alemtuzumab on CD4+ Lymphocytes in Multiple Sclerosis Patients: A 72-Month Follow-Up
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.818325
Abstract: Introduction Alemtuzumab is highly effective in the treatment of patients with relapsing multiple sclerosis (PwRMS) and selectively targets the CD52 antigen, with a consequent profound lymphopenia, particularly of CD4+ T lymphocytes. However, the immunological basis… read more here.
Keywords: cd4; month; long term; cd4 lymphocytes ... See more keywords