Mutation in the D1 domain of CD4 receptor modulates the binding affinity to HIV-1 gp120
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DOI: 10.1039/d2ra06628a
Abstract: The gp120 surface subunit of HIV-1 envelope lycoprotein (Env) is the key component for the viral entry process through interaction with the CD4 binding site (CD4bs) of the primary receptor CD4. The point mutant was… read more here.
Keywords: cd4 receptor; gp120; hiv gp120; cd4 ... See more keywords
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2025914118
Abstract: Significance The CD4 protein of primates has undergone rapid diversification, but the reasons for this remain unknown. Here we show that within-species diversity of the HIV/simian immunodeficiency virus (SIV) envelope (Env) binding (D1) domain is… read more here.
Keywords: cd4 receptor; diversity; primate lentiviruses; primate ... See more keywords