A Polyvalent Peptide CD40 Nanoagonist for Targeted Modulation of Dendritic Cells and Amplified Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109432
Abstract: Targeted immunomodulation through biomolecule‐based nanostructures, especially to dendritic cells (DCs), holds great promise for effective cancer therapy. However, construction of high‐performance agonist by mimicking natural ligand to activate immune cell signaling is a great challenge… read more here.
Keywords: pva cd40; polyvalent peptide; cd40; dendritic cells ... See more keywords
Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation
Sign Up to like & getrecommendations! Published in 2023 at "Small Methods"
DOI: 10.1002/smtd.202200925
Abstract: Immune intervention of B cell activation to blockade the production of autoantibodies provokes intense interest in the field of systemic lupus erythematosus (SLE) therapy development. Although the survival rate for SLE is improved, many patients… read more here.
Keywords: engineered cell; cell; cell membrane; cd40 nvs ... See more keywords
CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4893-2
Abstract: To the Editor: The CD40-CD40 ligand (CD40L, also known as CD154) pathway has been identified as a potential target for pharmaceutical intervention in type 1 diabetes [1, 2]. The CD40-targeted peptide approach published by Wagner… read more here.
Keywords: affinity; mer peptide; cd40l; cd40 ... See more keywords
B-cell subsets imbalance and reduced expression of CD40 in ataxia-telangiectasia patients.
Sign Up to like & getrecommendations! Published in 2018 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2017.09.031
Abstract: BACKGROUND Ataxia-telangiectasia (AT) is a well-known primary immunodeficiency with recurrent sinopulmonary infections and variable abnormalities in both the humoral and cellular immune system. Dysfunctions in immunoglobulin production, reduced number of B cells, and B-cell receptor… read more here.
Keywords: expression cd40; ataxia telangiectasia; cell subsets; cd40 ... See more keywords
RIP1 has a role in CD40-mediated apoptosis in human follicular lymphoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2017.06.001
Abstract: CD40 is a cell surface receptor which belongs to tumor necrosis factor receptor (TNFR) family members. It transmits signals that regulate diverse cellular responses such as proliferation, differentiation, adhesion molecule expression and apoptosis. Unlike other… read more here.
Keywords: apoptosis; trail; induced apoptosis; follicular lymphoma ... See more keywords
Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.151899
Abstract: Generation of an accurate humoral and a cell mediated adaptive immune responsesare dictated by binding of an antigen to a T- and a B-cell receptor, respectively (first signal) followed by ligation of costimulatory molecules (second… read more here.
Keywords: immune; cd40 cd40l; cancer autoimmune; autoimmune disorders ... See more keywords
Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of Non-obese Diabetic Mice with Sjögren's Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.07.005
Abstract: BACKGROUND Overexpression of CD40 has been reported in patients with primary Sjögren's syndrome (pSS). The increased CD40 expression promote autoimmune response and enhance inflammation in pSS. The aim of this study is to block CD40-CD154… read more here.
Keywords: cd40 dna; pathology; dna vaccine; cd40 ... See more keywords
Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-d-aspartate receptor encephalitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577762
Abstract: Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration… read more here.
Keywords: methyl aspartate; anti nmdare; cd40l; anti methyl ... See more keywords
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM2.5.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152993
Abstract: Fine particulate matter (PM2.5) exposure can cause the injury of vascular endothelial cells by inflammatory response. CD40 works in inflammation of endothelial cells and it may be regulated by the miRNAs. This study aimed to… read more here.
Keywords: pm2; mir 145; apoptosis; inflammation ... See more keywords
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01572-7
Abstract: CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to prime tumor-specific CD8+ T cell responses. Here, we study the antitumor activity and mechanism of action of a nonreplicating adenovirus encoding a… read more here.
Keywords: eradication; melanoma; checkpoint blockade; cd40 ... See more keywords
Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49040-0
Abstract: Platelet transfusions can cause adverse reactions in their recipients, including transfusion-related acute lung injury (TRALI). The pathophysiology of TRALI depends on a number of signaling pathways and the inflammatory role played by blood platelets remains… read more here.
Keywords: related acute; transfusion related; cd40l; cd40 ... See more keywords