Anti‐CD40 antibody 2C10 binds to a conformational epitope at the CD40‐CD154 interface that is conserved among primate species
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15574
Abstract: The antagonistic anti‐CD40 antibody, 2C10, and its recombinant primate derivative, 2C10R4, are potent immunosuppressive antibodies whose utility in allo‐ and xenotransplantation have been demonstrated in nonhuman primate studies. In this study, we defined the 2C10… read more here.
Keywords: cd40 antibody; anti cd40; cd40; 2c10 binding ... See more keywords
Developing a translational murine‐to‐canine pathway for an IL‐2/agonist anti‐CD40 antibody cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary and Comparative Oncology"
DOI: 10.1111/vco.12813
Abstract: Abstract Human and canine sarcomas are difficult to treat soft tissue malignancies with an urgent need for new improved therapeutic options. Local recurrence rates for humans are between 10%–30%, and 30%–40% develop metastases. Outcomes for… read more here.
Keywords: cd40 antibody; cancer; canine; cd40 ... See more keywords