IL-1 and CD40/CD40L platelet complex: elements of induction of Crohn’s disease and new therapeutic targets
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-020-01296-1
Abstract: Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic and multifactorial diseases that affect the intestinal tract, both characterized by recurrent inflammation of the intestinal mucosa, resulting in abdominal pain, diarrhea, vomiting and, rectal bleeding.… read more here.
Keywords: cd40 cd40l; platelet complex; cd40l platelet; platelet ... See more keywords
Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.151899
Abstract: Generation of an accurate humoral and a cell mediated adaptive immune responsesare dictated by binding of an antigen to a T- and a B-cell receptor, respectively (first signal) followed by ligation of costimulatory molecules (second… read more here.
Keywords: immune; cd40 cd40l; cancer autoimmune; autoimmune disorders ... See more keywords
CD40-CD40L Blockade: Update on Novel Investigational Therapeutics for Transplantation.
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004469
Abstract: Effective immune responses require antigen presentation by major histocompatibility complexes with cognate T-cell receptor and antigen-independent costimulatory signaling for T-cell activation, proliferation, and differentiation. Among several costimulatory signals, CD40-CD40L is of special interest to the… read more here.
Keywords: cd40l blockade; transplantation cd40; transplantation; cd40 cd40l ... See more keywords
Causal associations between CD40/CD40L and aortic diseases: A mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.998525
Abstract: Background: CD40 and CD40L have been reported as associated with aortic dissection (AD) and aortic aneurysm (AA), but the causality of the associations has not been established yet. Methods: We conducted a two-sample Mendelian randomization… read more here.
Keywords: study; mendelian randomization; cd40 cd40l; causal ... See more keywords
Anti-CD40 Antibody Fused to CD40 Ligand Is a Superagonist Platform for Adjuvant Intrinsic DC-Targeting Vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.786144
Abstract: CD40 is a potent activating receptor expressed on antigen-presenting cells (APCs) of the immune system. CD40 regulates many aspects of B and T cell immunity via interaction with CD40L expressed on activated T cells. Targeting… read more here.
Keywords: antigen; cd40; cd40 cd40l; anti cd40 ... See more keywords