CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4893-2
Abstract: To the Editor: The CD40-CD40 ligand (CD40L, also known as CD154) pathway has been identified as a potential target for pharmaceutical intervention in type 1 diabetes [1, 2]. The CD40-targeted peptide approach published by Wagner… read more here.
Keywords: affinity; mer peptide; cd40l; cd40 ... See more keywords
Platelet CD40L induces activation of astrocytes and microglia in hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.09.021
Abstract: Studies have demonstrated separately that hypertension is associated with platelet activation in the periphery (resulting in accumulation and localized inflammatory response) and glial activation in the brain. We investigated the contribution of platelets in brain… read more here.
Keywords: activation astrocytes; astrocytes microglia; cd40l; activation ... See more keywords
Association of plasma CD40L with acute chest syndrome in sickle cell anemia
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.05.017
Abstract: &NA; Platelet activation and platelet‐derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet‐associated pro‐inflammatory molecule that promotes endothelial… read more here.
Keywords: acs; cd40l; cell; platelet ... See more keywords
Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-d-aspartate receptor encephalitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577762
Abstract: Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration… read more here.
Keywords: methyl aspartate; anti nmdare; cd40l; anti methyl ... See more keywords
A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2016.12.008
Abstract: West Nile Virus (WNV) is endemic in the US and causes severe neurologic disease in horses since its introduction in 1999. There is no effective pharmaceutical treatment for WNV infection rendering vaccination as the only… read more here.
Keywords: protein; cd40l; west nile; virus ... See more keywords
TRAF3 negatively regulates platelet activation and thrombosis
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DOI: 10.1038/s41598-017-17189-1
Abstract: CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L.… read more here.
Keywords: cd40l; platelet activation; activation; traf3 ... See more keywords
Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49040-0
Abstract: Platelet transfusions can cause adverse reactions in their recipients, including transfusion-related acute lung injury (TRALI). The pathophysiology of TRALI depends on a number of signaling pathways and the inflammatory role played by blood platelets remains… read more here.
Keywords: related acute; transfusion related; cd40l; cd40 ... See more keywords
3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2025694
Abstract: ABSTRACT The implications of the CD40-CD40 ligand (CD40L) signaling pathway in systemic lupus erythematosus (SLE) were well documented, due to its important role among immune cells. Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2),… read more here.
Keywords: sle; cd40l; cd4 cells; demethylation ... See more keywords
Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques
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DOI: 10.1128/jvi.01933-19
Abstract: CD40-CD40 ligand (CD40L) interaction is crucial for inducing effective cytotoxic and humoral responses against pathogens. Because of its immunomodulatory function, CD40L has been used to enhance immune responses to vaccines, including candidate vaccines for HIV.… read more here.
Keywords: cd4; virus; cd40l; alvac ... See more keywords
Abstract 5567: Agonist redirected checkpoint (ARC), SIRPα-Fc-CD40L, for cancer immunotherapy
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DOI: 10.1158/1538-7445.am2018-5567
Abstract: Current attempts at combination immunotherapy with bispecific antibodies, linked scFv9s or T cell engagers have not demonstrated that both checkpoint blockade and TNF receptor activation can be achieved with a single molecule. This is likely… read more here.
Keywords: arc; cd40l; checkpoint; cancer ... See more keywords
Abstract 1534: MEDI5083, a novel CD40L-Fc fusion protein, activates the CD40 pathway on antigen presenting cells and promotes a robust anti-tumor immune response in a B16F10 murine tumor model
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-1534
Abstract: Targeting CD40 with its natural ligand (CD40L) enhances the immune-stimulatory functions of dendritic cells, B cells, monocytes and macrophages, resulting in T cell priming, expansion and differentiation. Thus, activation of the CD40 pathway is an… read more here.
Keywords: anti tumor; medi5083; tumor immune; cd40 pathway ... See more keywords