Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14169
Abstract: Sialic acid‐binding immunoglobulin‐like lectin‐15 (Siglec‐15) has been identified as a novel potential target for cancer immunotherapy. Here, we explored the role of Siglec‐15 in human hepatoma cells. In this study, we found that the expression… read more here.
Keywords: siglec; hepatoma cells; promotes migration; cd44 ... See more keywords
Glioblastoma Spheroid Invasion through Soft, Brain‐Like Matrices Depends on Hyaluronic Acid–CD44 Interactions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203143
Abstract: Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) patients. GBM cells aggressively invade the brain parenchyma while encountering spatiotemporal changes… read more here.
Keywords: cell; cd44; brain; concentration ... See more keywords
Evaluation of correlation between CD44, radiotherapy response, and survival rate in patients with advanced stage of head and neck squamous cell carcinoma (HNSCC)
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4497
Abstract: Cancer stem cells (CSCs) constitute a distinctive subpopulation of cancer cells that are competent in tumor initiation, invasion, recurrence, and resistance to chemoradiotherapy. CD44, a hyaluronic acid (HA) receptor has been considered as a potential… read more here.
Keywords: cd44; head neck; response survival; correlation cd44 ... See more keywords
Hyaluronan‐binding by CD44 reduces the memory potential of activated murine CD8 T cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747263
Abstract: Expansion and death of effector CD8 T cells are regulated to limit immunopathology and cells that escape contraction go on to generate immunological memory. CD44, a receptor for the extracellular matrix component hyaluronan, is a… read more here.
Keywords: cd8; binding cd44; cd8 cells; hyaluronan binding ... See more keywords
LncRNA DGCR5 contributes to CSC‐like properties via modulating miR‐330‐5p/CD44 in NSCLC
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26590
Abstract: Non‐coding RNAs can exert significant roles various cancers, including NSCLC. Previously, we indicated that lncRNA DGCR5 can promote lung cancer progression through inhibiting hsa‐mir‐22‐3p. In our current study, we investigated the role of DGCR5 in… read more here.
Keywords: nsclc; csc like; dgcr5; cd44 ... See more keywords
β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12203
Abstract: Abstract Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD), suggesting intimate communication between the two types of cells. However, the underlying mechanisms remain to be determined. Exosomes play a… read more here.
Keywords: cd44; catenin controlled; role; exosomes play ... See more keywords
A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2549
Abstract: The clinical effectiveness of systemically administered human mesenchymal stem cells (hMSCs) depends on their capacity to engage vascular endothelium. hMSCs derived from bone marrow (BM‐hMSCs) natively lack endothelial binding capacity, but express a CD44 glycovariant… read more here.
Keywords: hmscs; human mesenchymal; cd44; expression ... See more keywords
ESRP1‐Induced CD44 v3 Is Important for Controlling Pluripotency in Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2864
Abstract: The importance of alternative splicing (AS) events in pluripotency regulation has been highlighted by the determination of different roles and contributions of different splice isoforms of pluripotency‐related genes and by the identification of distinct pluripotency‐related… read more here.
Keywords: esrp1; human pluripotent; pluripotency; cd44 ... See more keywords
EHD1 promotes the cancer stem cell (CSC)‐like traits of glioma cells via interacting with CD44 and suppressing CD44 degradation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23592
Abstract: Plenty of evidence has shown that endocytosis plays a key role in cancer progression; however, its effects in the progression of cancer stem cells (CSCs) are still fragmentary. In the present study, we firstly identified… read more here.
Keywords: cd44; like traits; glioma cells; csc like ... See more keywords
Helicobacter pylori infection and gastrointestinal tract cancer biology: considering a double-edged sword reflection
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03106-4
Abstract: In their comprehensive review Mentis et al. [1] discussed some molecular biological mechanisms involved in Helicobacter pylori infection (Hp-I)-related gastric cancer (GC) biology such as the role of stem cells and the link between Hp-I… read more here.
Keywords: bmdscs; cd44; biology; cancer ... See more keywords
miRNA-34a inhibits cell adhesion by targeting CD44 in human renal epithelial cells: implications for renal stone disease
Sign Up to like & getrecommendations! Published in 2019 at "Urolithiasis"
DOI: 10.1007/s00240-019-01155-9
Abstract: Nephrolithiasis is a very common disease in which cell–crystal adhesion is an essential mechanism for kidney stone formation. This study has explored the anti-adhesion function of the microRNA, miR-34a, by targeting CD44, a cell surface… read more here.
Keywords: stone; mir 34a; adhesion; disease ... See more keywords