Self-targeted knockdown of CD44 improves cisplatin sensitivity of chemoresistant non-small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3737-y
Abstract: BackgroundChemoresistance remains a major challenge for effective chemotherapy of non-small-cell lung carcinoma (NSCLC). CD44 expression is related to the susceptibility of various cancer cell types to anticancer drugs. Here, we systematically investigated the CD44-dependent chemoresistance… read more here.
Keywords: self targeted; nsclc cells; cd44; cell ... See more keywords
The PBX1 lupus susceptibility gene regulates CD44 expression
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.02.016
Abstract: &NA; PBX1‐d is novel splice isoform of pre‐B‐cell leukemia homeobox 1 (PBX1) that lacks its DNA‐binding and Hox‐binding domains, and functions as a dominant negative. We have shown that PBX1‐d expression in CD4+ T cells… read more here.
Keywords: pbx1; expression; isoform pbx1; expression pbx1 ... See more keywords
95 The roles of CD44 expression and the combination of CD133, CD44, ALDH1A1 expressions in chemotherapy response of epithelial type ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-igcs.95
Abstract: Objectives Determining the roles of CD44 expression and the combination of CD133, CD44, ALDH1A1 expressions in chemotherapy response of epithelial-type ovarian cancer. Methods Ambispective cohort (retrospective and prospective). The subject of this study was 55… read more here.
Keywords: ovarian cancer; cd44 expression; cd133; cancer ... See more keywords
Relationship between Ki-67 and CD44 expression and microvascular formation in gastric stromal tumor tissues
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DOI: 10.12998/wjcc.v10.i2.469
Abstract: BACKGROUND A gastric stromal tumor (GST) is a mesenchymal tumor that occurs in the gastrointestinal tract; its biological characteristics are highly complex. Clinically, the severity of a GST is often evaluated by factors such as… read more here.
Keywords: cd44 expression; gastric stromal; expression; risk ... See more keywords
CD44 Expression Profile Varies According to Maturational Subtypes and Molecular Profiles of Pediatric T-Cell Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00488
Abstract: CD44 is a glycoprotein expressed in leucocytes and a marker of leukemia-initiating cells, being shown to be important in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). In this study, we have (i) identified… read more here.
Keywords: lymphoblastic leukemia; cd44; expression; cell ... See more keywords
New Horizons in Metastatic Colorectal Cancer: Prognostic Role of CD44 Expression
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DOI: 10.3390/cancers15041212
Abstract: Simple Summary In our study, we analyzed the role of CD44 expression as a prognostic marker in patients with metastatic colorectal cancer. CD44 is a multi-structural and multifunctional non-kinase transmembrane glycoprotein. Its expression is recognized… read more here.
Keywords: cd44; cd44 expression; role; expression ... See more keywords
NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44
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DOI: 10.3390/ijms21061927
Abstract: CD44, a cancer stem cell (CSC) marker, is required for maintaining CSC properties in hepatocellular carcinoma (HCC). Nuclear enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), is an oncogenic driver in HCC. In… read more here.
Keywords: csc; csc properties; marker; expression ... See more keywords
CD44 Expression in Renal Tissue Is Associated with an Increase in Urinary Levels of Complement Components in Chronic Glomerulopathies
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087190
Abstract: It is suggested that activated CD44+ cells play a profibrogenic role in the pathogenesis of active glomerulopathies. Complement activation is also involved in renal fibrogenesis. The aim of the study was to evaluate the role… read more here.
Keywords: cd44; complement components; cd44 expression; renal tissue ... See more keywords
Hypoxia regulates CD44 expression via hypoxia-inducible factor-1α in human gastric cancer cells.
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DOI: 10.3892/ol.2016.5473
Abstract: Hypoxia induces proliferation and invasion in cancer cells via hypoxia-inducible factor (HIF)-1α. The cell adhesion molecule cluster of differentiation (CD) 44 has been associated with increased cell invasion and metastasis. Whether hypoxia regulates the expression… read more here.
Keywords: invasion; expression; cancer cells; hypoxia ... See more keywords
Elevated CD44 expression predicts poor prognosis in patients with low-grade glioma
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DOI: 10.3892/ol.2019.10728
Abstract: CD44 is involved in malignant processes including cell motility, tumor growth and angiogenesis. To explore the potential role of CD44 as a prognostic biomarker in low grade gliomas (LGG), the mRNA expression levels of CD44… read more here.
Keywords: elevated cd44; expression predicts; expression; low grade ... See more keywords
Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential
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DOI: 10.7150/jca.19633
Abstract: Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The… read more here.
Keywords: expression snail; expression; ectopic expression; leukemia ... See more keywords