Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.09.043
Abstract: Targeting of CD44 isoforms containing exon v6 (CD44v6) represents a viable strategy for the therapy and/or early diagnosis of metastatic cancers of the epithelium (e.g. gastric and colorectal cancer). We developed and characterized poly(lactic-co-glycolic acid)… read more here.
Keywords: cells expressing; cd44v6; fab plga; plga nps ... See more keywords
CD44 variant 6 is associated with prostate cancer growth and chemo-/radiotherapy response in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111850
Abstract: We have previously demonstrated that CD44 variant 6 (CD44v6) is associated with prostate cancer (CaP) growth and therapeutic resistance in vitro, however, the role of CD44v6 in CaP in vivo is not fully understood. The… read more here.
Keywords: radiotherapy response; cd44v6; growth chemo; chemo radiotherapy ... See more keywords
Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery"
DOI: 10.1080/10717544.2021.1914777
Abstract: Abstract Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid… read more here.
Keywords: oha lipid; cd44v6; lipid oxa; colorectal cancer ... See more keywords
CD44v6+ Hepatocellular Carcinoma Cells Maintain Stemness Properties through Met/cJun/Nanog Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/5853707
Abstract: Cancer stem cells (CSCs) are characterized by their self-renewal and differentiation abilities. CD44v6 is a novel CSC marker that can activate various signaling pathways. Here, we hypothesized that the HGF/Met signaling pathway promotes stemness properties… read more here.
Keywords: hcc cells; cjun; site; cd44v6 ... See more keywords
Abstract 3960: The allosteric inhibitor of CD44v6 AMC303 blocks c-MET, Ron and VEGFR-2 dependent signaling and cellular processes
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3960
Abstract: Introduction: In cancer patients, the development of metastases is associated with a poor clinical prognosis. Metastatic dissemination requires cancer cells to detach from the primary tumor and invade adjacent or distant tissue. This process involves… read more here.
Keywords: cd44v6; vegfr; amc303; met ron ... See more keywords
Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.906260
Abstract: Chemoresistance in colorectal cancer initiating cells (CICs) involves the sustained activation of multiple drug resistance (MDR) and WNT/β-catenin signaling pathways, as well as of alternatively spliced-isoforms of CD44 containing variable exon-6 (CD44v6). In spite of… read more here.
Keywords: wnt catenin; resistance; colorectal cancer; catenin ... See more keywords
Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.906415
Abstract: Cancer-initiating cells (CICs) drive colorectal tumor growth by their supportive niches where CICs interact with multiple cell types within the microenvironment, including cancer-associated fibroblasts (CAFs). We investigated the interplay between the CICs and the clinically… read more here.
Keywords: cancer; tumor growth; initiating cells; cancer associated ... See more keywords
Next Generation CD44v6-Specific CAR-NK Cells Effective against Triple Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109038
Abstract: There is a medical need to develop new and effective therapies against triple-negative breast cancer (TNBC). Chimeric antigen receptor (CAR) natural killer (NK) cells are a promising alternative to CAR-T cell therapy for cancer. A… read more here.
Keywords: triple negative; car; cd44v6; car cells ... See more keywords
Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oncology"
DOI: 10.3892/ijo.2018.4364
Abstract: CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for… read more here.
Keywords: radio immunotherapy; cd44v6; antibody; abn44v6 ... See more keywords
CD44v6 may influence ovarian cancer cell invasion and migration by regulating the NF-κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10306
Abstract: Ovarian cancer (OC) has the worst prognosis among all malignancy types in females worldwide according to epidemiological studies in 2017. Although radiotherapy, chemotherapy and surgical treatment are the most common treatment methods, their curative effects… read more here.
Keywords: invasion; control; cd44v6; group ... See more keywords
CD44v6 Targeted by miR-193b-5p in the Coding Region Modulates the Migration and Invasion of Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.35067
Abstract: Previous studies have shown that CD44 containing variant exon v6 (CD44v6) is highly expressed in many cancers and is related to tumor metastasis. However, the detailed mechanism of the regulatory pattern of CD44v6 in breast… read more here.
Keywords: cd44v6; breast cancer; cancer; mir 193b ... See more keywords