Microfluidic enrichment of plasma cells improves treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12201
Abstract: Cytogenetic alterations form the basis for risk stratification for multiple myeloma (MM) and guide the selection of therapy; however, current pathology assays performed on bone marrow samples can produce false‐negatives due to the unpredictable distribution… read more here.
Keywords: cytogenetic alterations; multiple myeloma; plasma cells; cd45 ... See more keywords
The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646405
Abstract: The cytoplasmic tail of CD45 (ct‐CD45) is proteolytically cleaved and released upon activation of human phagocytes. It acts on T cells as an inhibitory, cytokine‐like factor in vitro. Here, we show that ct‐CD45 is abundant… read more here.
Keywords: plasma; cd45 cd45; human plasma; cytoplasmic tail ... See more keywords
Human Umbilical Cord Blood CD45+ Pan-Hematopoietic Cells Induced a Neurotherapeutic Effect in Mice with Traumatic Brain Injury: Immunophenotyping, Comparison of Maternal and Neonatal Parameters, and Immunomodulation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-1008-8
Abstract: Human umbilical cord blood (HUCB) transplantation has become an alternative cell therapy for hematological and oncological malignancies in the clinic and is considered for neurological disorders. The heterogeneity in the content of the different stem… read more here.
Keywords: neurotherapeutic effect; pan hematopoietic; cd45 pan; hucb ... See more keywords
CD45-Targeted Antibody Drug Conjugate Plus Post Transplant Cytoxan Is Sufficient to Enable Allogeneic Bone Marrow Transplant in a Minor Mismatch Mouse Model
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.775
Abstract: Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or conditioning, prior to BMT limit the use of this curative procedure due to regimen-related… read more here.
Keywords: cd45; cd45 sap; bone marrow; transplant ... See more keywords
Splenic γδ T cell subsets can be separated by a novel mab specific for two CD45 isoforms.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2017.08.013
Abstract: CD45 isoforms have been identified in a variety of different species and mab against various isoforms have been instrumental to define cellular subsets. In the process of generating novel mab against chicken γδ T cells… read more here.
Keywords: cd45 isoforms; novel mab; splenic cell; cell subsets ... See more keywords
Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.05.006
Abstract: Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer… read more here.
Keywords: mouse models; variation; variation widely; immune responses ... See more keywords
Loss of CD45 cell surface expression in canine T-zone lymphoma results from reduced gene expression.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2017.03.006
Abstract: Canine T-zone lymphoma (TZL) is a peculiar lymphoma subtype characterized by an indolent clinical course and aberrant CD45-negative phenotype, commonly recognized by flow cytometry (FC). Recent studies have described clinical presentation and behavior, but to… read more here.
Keywords: canine; expression; gene; cell ... See more keywords
Resveratrol decreases CD45+CD206− subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14680
Abstract: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are life‐threatening condition in critically ill patients. Resveratrol (Res), a natural polyphenol, has therapeutic effect in animal model with ALI; however, whether Res attenuates ALI through modulation of… read more here.
Keywords: lps induced; cd206 subtype; cd45 cd206; induced murine ... See more keywords
Local immune response to larvae of Rhipicephalus microplus in Santa Gertrudis cattle
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DOI: 10.1111/pim.12515
Abstract: This study investigated the local immune response at larval attachment sites in Santa Gertrudis cattle with low and high levels of tick resistance. Skin samples with tick larvae attached were collected from Santa Gertrudis cattle… read more here.
Keywords: local immune; immune response; santa gertrudis; gertrudis cattle ... See more keywords
Nodal T-zone lymphoma and T-zone hyperplasia in dogs
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Pathology"
DOI: 10.1177/03009858221102599
Abstract: T-zone lymphoma (TZL) is an indolent, nodal lymphoma that has been clinically characterized in detail in dogs, and T-zone hyperplasia (TZH) is a hyperplastic change in lymph nodes associated with antigen processing. In some cases,… read more here.
Keywords: lymphoma; zone hyperplasia; zone; cd45 ... See more keywords
Large Stem/Progenitor-Like Cell Subsets can Also be Identified in the CD45- and CD45+/High Populations in Early Human Milk
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Human Lactation"
DOI: 10.1177/0890334419885315
Abstract: Background Stem/progenitor cells have been identified in human milk. However, characterization and percentages of cell subsets in human milk using hematopoietic stem and progenitor cell markers according to the differential expression of CD45, i.e., as… read more here.
Keywords: milk; stem progenitor; human milk; cd45 ... See more keywords