CD45RA-CD25highCD127-CD4+ activated regulatory T cells are correlated with de novo donor-specific anti-HLA antibody formation after kidney transplantation in standard immunosuppression.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107661
Abstract: Although de novo donor-specific anti-HLA antibodies (dnDSA) remain a barrier for human kidney transplantation (KTx), the role of regulatory T (Treg) cells in dnDSA formation remains unknown. To address this question, we evaluated Treg cell… read more here.
Keywords: cd45ra; donor specific; cd25highcd127 cd4; formation ... See more keywords
Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion
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DOI: 10.1038/s41598-019-41803-z
Abstract: Priming haematopoietic stem/progenitor cells (HSPCs) in vitro with specific chromatin modifying agents and cytokines under serum-free-conditions significantly enhances engraftable HSC numbers. We extend these studies by culturing human CD133+ HSPCs on nanofibre scaffolds to mimic… read more here.
Keywords: cd34; expansion; cd38; lin cd34 ... See more keywords
Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells
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DOI: 10.1038/s41598-021-88448-5
Abstract: Resting and activated subpopulations of CD4+CD25+CD127loT regulatory cells (Treg) and CD4+CD25+CD127+ effector T cells in MS patients and in healthy individuals were compared. Peripheral blood mononuclear cells isolated using Ficoll Hypaque were stained with monoclonal… read more here.
Keywords: cd4 cd25; cd25; treg; population ... See more keywords
Potent anti-tumor activity of CD45RA-targeting Hm3A4-Ranpirnase against myeloid lineage leukemias
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DOI: 10.1080/21655979.2022.2054159
Abstract: ABSTRACT CD45RA is a specific marker for leukemia stem cell (LSC) sub-populations in acute myeloid leukemia (AML). Ranpirnase (Rap), an amphibian RNase, has been extensively investigated in preclinical and clinical studies for its antitumor activity.… read more here.
Keywords: immunotoxin; activity; potent anti; rap ... See more keywords
Sequential Infusion of Tcrαβ- and CD45RA-Depleted Haploidentical Progenitor Cells Is Safe and Allows for Rapid Immune Reconstitution in Pediatric Patients with Recurrent Hematological Malignancies
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DOI: 10.1182/blood-2018-99-110886
Abstract: Background: Haploidentical hematopoietic cell transplantation (haploHCT) is an attractive option for patients, who have no suitable matched-related or -unrelated donor. While the increased alloreactivity of haploidentical grafts enhances graft-vs-leukemia effects, it also increases the risk… read more here.
Keywords: cell; cd45ra; immune reconstitution; tcr cd45ra ... See more keywords
Different Subsets of Haematopoietic Cells and Immune Cells in Bone Marrow between Young and Old Donors
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DOI: 10.1182/blood-2020-134758
Abstract: Background Young donors are reported to be associated with better transplant outcomes than old donors in allo-HSCT, but the underlying mechanism is still uncertain. Successful allo-HSCT relies on the rapid reconstitution of donor-derived haematopoietic and… read more here.
Keywords: cd34 cd38; frequency; cd45ra; old donors ... See more keywords