Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13084
Abstract: Cluster of differentiation 47 (CD47) is a widely expressed self‐protection transmembrane protein that functions as a critical negative regulator to induce macrophage‐mediated phagocytosis. Overexpression of CD47 enables cancer cells to escape immune surveillance and destruction… read more here.
Keywords: cd47 antibody; cd47; antibody; anti cd47 ... See more keywords
A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.05.019
Abstract: Strategies for targeting CD47 are becoming a hot spot of cancer immunotherapy. However the ubiquitous expression of CD47, especially on the RBC, makes the targeted therapy facing safety risk issues. So, how to balance the… read more here.
Keywords: cd47 antibody; novel fully; cd47; antibody ... See more keywords
Anti‐CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non‐alcoholic steatohepatitis models
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15182
Abstract: With the epidemic burden of obesity and metabolic diseases, nonalcoholic fatty liver disease (NAFLD) including steatohepatitis (NASH) has become the most common chronic liver disease in the western world. NASH may progress to cirrhosis and… read more here.
Keywords: antibody treatment; steatohepatitis; cd47 antibody; treatment ... See more keywords
Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-1079
Abstract: Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal tissues and overexpressed on many tumors. Binding of tumor CD47 to signal regulatory… read more here.
Keywords: anti cd47; cd47 antibody; next generation; cell ... See more keywords
CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages impairing recovery in EAE.
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DOI: 10.1172/jci.insight.148719
Abstract: Experimental Autoimmune Encephalomyelitis (EAE) is a well-characterized animal model of Multiple Sclerosis. During the early phase of EAE, the infiltrating monocyte and monocyte-derived macrophages and activated resident microglia contribute to T cell recruitment, especially CD4+… read more here.
Keywords: recovery; cd47 antibody; phagocytosis; cd47 ... See more keywords
Platelet Membrane-Coated Nanocarriers Targeting Plaques to Deliver Anti-CD47 Antibody for Atherosclerotic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Research"
DOI: 10.34133/2022/9845459
Abstract: Atherosclerosis, the principle cause of cardiovascular disease (CVD) worldwide, is mainly characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris. Atherogenesis is associated with the upregulation of CD47, a key antiphagocytic… read more here.
Keywords: cd47 antibody; anti cd47; platelet membrane; therapy ... See more keywords