A comprehensive analysis of CD47 expression in various histological subtypes of soft tissue sarcoma: exploring novel opportunities for macrophage-directed treatments
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-024-05661-1
Abstract: The CD47 molecule, often referred to as the “do not eat me” signal, is frequently overexpressed in tumor cells. This signaling pathway limits phagocytosis by macrophages. Our objective was to determine CD47 abundance in various… read more here.
Keywords: abundance; sarcoma; tumor; cd47 expression ... See more keywords
Nanobody-Based PET Imaging of CD47 Expression in Thyroid Carcinoma.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00284
Abstract: Thyroid cancer is the most common malignant tumor in the endocrine system. A significant correlation has been established between elevated CD47 expression and the progression of thyroid carcinoma. This study aims to evaluate the diagnostic… read more here.
Keywords: thyroid cancer; 68ga nota; cd47 expression; tumor ... See more keywords
Checkpoint CD47 expression in classical Hodgkin lymphoma
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DOI: 10.1111/bjh.18137
Abstract: The glycoprotein CD47 regulates antiphagocytic activity via signal regulatory protein alpha (SIRPa). This study investigated CD47 expression on Hodgkin and Reed–Sternberg (HRS) cells in the classical Hodgkin lymphoma (cHL) tumour microenvironment and its correlation with… read more here.
Keywords: hodgkin lymphoma; classical hodgkin; expression; cd47 ... See more keywords
Clinicopathological significance of CD47 expression in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-206611
Abstract: Aims CD47 is upregulated on the surface of various tumour cells, and it is known to inhibit the phagocytosis of tumour cells by macrophages. Immunotherapy that targets CD47 has demonstrated success in preclinical trials and… read more here.
Keywords: hepatocellular carcinoma; cd47 expression; expression; expression hepatocellular ... See more keywords
Expression of CD47 in Endometrial Cancer and Its Clinicopathological Significance
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DOI: 10.1155/2022/7188972
Abstract: Purpose To study the prognostic value of CD47 in endometrial carcinoma (EC) and its correlation with clinicopathological variables. Methods Next-generation sequencing data from The Cancer Genome Atlas was analyzed with the Kaplan–Meier curve, Cox's regression… read more here.
Keywords: cancer; endometrium hyperplasia; cd47 expression; expression ... See more keywords
Impact of Mutational Landscape and CD47 Levels in the Magrolimab + Azacitidine Vs Placebo + Azacitidine Trial in Patients with Untreated Higher Risk Myelodysplastic Syndrome
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DOI: 10.1182/blood-2024-210894
Abstract: Background Magrolimab (Hu5F9-G4) is a monoclonal antibody that blocks CD47, an antiphagocytic signal largely overexpressed on tumor cells, but also ubiquitously expressed on non-neoplastic cells of myeloid origin. Following promising Ph 1 clinical data, the… read more here.
Keywords: cd47 expression; risk; cd47; magrolimab aza ... See more keywords
CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20187784
Abstract: Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is… read more here.
Keywords: progenitor cells; hematopoietic progenitor; cells patients; cd47 expression ... See more keywords
CD47 expression in solid tumors correlates with phagocytic tumor-associated macrophage gene signature
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1699237
Abstract: Background CD47 is a “don’t eat me” signal that is overexpressed in tumors to evade phagocytosis by tumor associated macrophages (TAM). Investigational agents targeting CD47, such as magrolimab, aim to induce phagocytosis of tumor cells… read more here.
Keywords: macrophage; tumor; cd47 expression; expression ... See more keywords
Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer
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DOI: 10.3390/cancers14071801
Abstract: Simple Summary Cancer cells escape macrophage phagocytosis by exploiting the CD47/SIRPα axis. We found that extensive membranous CD47 expression by cancer cells characterized 29/98 cases. SIRPα and CD68 were expressed by tumor-associated macrophages (Μφ, TAMs).… read more here.
Keywords: cancer; expression; cd47 sirp; cancer cells ... See more keywords
Correlation of CD47 Expression with Adverse Clinicopathologic Features and an Unfavorable Prognosis in Colorectal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostics"
DOI: 10.3390/diagnostics11040668
Abstract: CD47, a transmembrane protein, is widely overexpressed on the tumor cell surface. However, the prognostic significance of CD47 expression in colorectal adenocarcinoma (CRA) has not yet been clarified. Here, we investigated the clinicopathologic significance of… read more here.
Keywords: adverse clinicopathologic; expression; cra; cd47 expression ... See more keywords
CD47 Expression Predicts Unfavorable Prognosis in Clear Cell Renal Cell Carcinoma after Curative Resection
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DOI: 10.3390/diagnostics12102291
Abstract: The role of CD47 expression as a ‘do not eat me’ signal that inhibits phagocytosis of tumor cells by macrophages is well established. Immune checkpoint therapy that targets CD47 has been successful in preclinical trials… read more here.
Keywords: cell renal; clear cell; cd47 expression; expression ... See more keywords