CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
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DOI: 10.1016/j.immuni.2020.07.008
Abstract: CD47 acts as a "don't eat me" signal that protects cells from phagocytosis by binding and activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro-engulfment "eat me" signals, including immunoglobulin G (IgG), complement,… read more here.
Keywords: phagocytosis; cd47; cd47 ligation; sirpa ... See more keywords