Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03815-z
Abstract: CD47, a transmembrane protein, acts as a “do not eat me” signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling… read more here.
Keywords: cd47 targeting; cd47; blockade; targeting agents ... See more keywords
CD47-targeting antibodies as a novel therapeutic strategy in hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2021.100268
Abstract: CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the “don't-eat-me” signal. However, accumulating evidence shows that solid and hematologic… read more here.
Keywords: cd47 targeting; strategy hematologic; therapeutic strategy; targeting antibodies ... See more keywords