Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response
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DOI: 10.1136/jitc-2022-004712
Abstract: Background CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular glycoprotein thrombospondin-1 (TSP1). We examined the impact of the CD47/TSP1 signaling axis on melanoma patient response to anti-PD-1 therapy… read more here.
Keywords: targeting cd47; melanoma; cd47 tsp1; cd47 ... See more keywords