Methods for Investigating VLA-4 (CD49d/CD29) Expression and Activation in Chronic Lymphocytic Leukemia and Its Clinical Applications.
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DOI: 10.1007/978-1-4939-8876-1_8
Abstract: The integrin heterodimer CD49d/CD29 (a.k.a. Very Late Antigen-4, VLA-4) mediates cell-cell and cell-matrix interaction through the binding of its ligands VCAM-1 and fibronectin. VLA-4 can be present on the cell surface at different conformation states… read more here.
Keywords: vla; lymphocytic leukemia; cd49d; expression ... See more keywords
Overexpression of CD49d in trisomy 12 chronic lymphocytic leukemia patients is mediated by IRF4 through induction of IKAROS
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DOI: 10.1038/s41375-018-0296-5
Abstract: In chronic lymphocytic leukemia (CLL), homing and retention of leukemic cells inside tissue niches represent crucial steps of disease progression. CLL trafficking from bloodstream into microenvironments is actively coordinated by transient interactions with endothelium through… read more here.
Keywords: cll; lymphocytic leukemia; cd49d; chronic lymphocytic ... See more keywords
Low CD49d expression in newly diagnosed chronic lymphocytic leukaemia may be associated with high‐risk features and reduced treatment‐free‐intervals
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DOI: 10.1111/ejh.13824
Abstract: This study was carried out to assess the prognostic power of low CD49d expression (≥10%) in newly diagnosed CLL patients using a previously described cohort. Eighty‐five patients were included. Median age at diagnosis; 70 years (43–88);… read more here.
Keywords: cd49d expression; expression; cd49d; low cd49d ... See more keywords
The VLA-4 Integrin Is Constitutively Activated in a Fraction of CD49d-Expressing Chronic Lymphocytic Leukemia Via Autonomous BCR-Mediated Signaling
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DOI: 10.1182/blood-2019-124313
Abstract: Introduction. In chronic lymphocytic leukemia (CLL), CD49d, the alpha chain of the heterodimer CD49d/CD29 (VLA-4), is a strong negative prognosticator, and a key player of CLL microenvironmental interactions. The adhesive properties of VLA-4 can be… read more here.
Keywords: bcr; vla; constitutive vla; cd49d ... See more keywords
CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression.
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DOI: 10.1182/blood.2019003179
Abstract: CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The extensively validated 30% of positive CLL cells cut-off value is able to separate CLL patients into two subgroups with different prognosis, but it… read more here.
Keywords: cll; sub population; bimodal expression; cd49d ... See more keywords