The therapeutic effect of IL-21 combined with IFN-γ inducing CD4+CXCR5+CD57+T cells differentiation on hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Advanced Research"
DOI: 10.1016/j.jare.2021.05.010
Abstract: Abstract Introduction Liver cancer is a malignant tumor with high incidence and short survival time. In order to increase the cure rate and disease-free survival rate of liver cancer, it is necessary to seek effective… read more here.
Keywords: cd57 cells; cd4 cxcr5; cxcr5 cd57;
CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-000639
Abstract: Background The repetitive antigen stimulation during chronic infection often leads to the accumulation of CD8+CD57+ T cells. These cells express high levels of interferon-γ, granzyme B and perforin with elevated cytolytic effect, and are considered… read more here.
Keywords: cd57; cd8 cd57; cancer; cd57 cells ... See more keywords
Functional Changes of T-Cell Subsets with Age and CMV Infection
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DOI: 10.3390/ijms22189973
Abstract: Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is associated with the expansion of polyfunctional CD57+ T-cells in young and… read more here.
Keywords: cmv infection; infection; cell subsets; age cmv ... See more keywords
mTOR Inhibition Impairs the Activation and Function of Belatacept-Resistant CD4+CD57+ T Cells In Vivo and In Vitro
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DOI: 10.3390/pharmaceutics15041299
Abstract: Calcineurin inhibitors have improved graft survival in solid-organ transplantation but their use is limited by toxicity, requiring a switch to another immunosuppressor in some cases. Belatacept is one option that has been shown to improve… read more here.
Keywords: cd57 cells; mtor; belatacept resistant; cd4 cd57 ... See more keywords