Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/1216048
Abstract: Methods A case–control study was conducted to investigate the SNPs at CD59 rs1047581, rs7046, rs2231460, rs184251026, rs41275164, rs831633, rs704700, rs41275166, and rs10768024 by sequence-specific primer-polymerase chain reaction (SSP-PCR) in 900 tuberculosis patients and 1,534 controls.… read more here.
Keywords: tuberculosis; infection; multiple cd59; showed significant ... See more keywords
CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-1072
Abstract: The subcellular compartmentalization of Ras is regulated by interacting with intracellular CD59. CD59 deficiency results in reduced trafficking of Ras to the plasma membrane in T cells, thus inducing increased T-cell signal transduction and antitumor… read more here.
Keywords: ras compartmentalization; regulated ras; compartmentalization; cd59 ... See more keywords
Serum CD59: a novel biomarker of idiopathic pulmonary fibrosis?
Sign Up to like & getrecommendations! Published in 2020 at "Panminerva medica"
DOI: 10.23736/s0031-0808.20.03893-8
Abstract: BACKGROUND Idiopathic pulmonary fibrosis (IPF) is the most common among idiopathic interstitial pneumonia. Life expectancy is estimated around 3-5 years at diagnosis. No reliable prognostic biomarker has been approved for routinary clinical practice of IPF.… read more here.
Keywords: serum; pulmonary fibrosis; serum cd59; idiopathic pulmonary ... See more keywords
Association Between Promoter Polymorphisms in CD46 and CD59 in Kidney Donors and Transplant Outcome
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00972
Abstract: Complement regulating proteins, including CD46, CD55, and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be involved in accommodation. Polymorphisms in their promoter regions may affect… read more here.
Keywords: kidney; rejection; promoter; cd46 ... See more keywords
Bispecific mAb2 Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095208
Abstract: Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer cells from a host immune system. This phenomenon extends to… read more here.
Keywords: cd20; complement dependent; complement; dependent cytotoxicity ... See more keywords
Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108561
Abstract: CD59 is an abundant immuno-regulatory human protein that protects cells from damage by inhibiting the complement system. CD59 inhibits the assembly of the Membrane Attack Complex (MAC), the bactericidal pore-forming toxin of the innate immune… read more here.
Keywords: complement; unveiling cd59; cd59; paratope mimicking ... See more keywords
Relative Contribution of Cellular Complement Inhibitors CD59, CD46, and CD55 to Parainfluenza Virus 5 Inhibition of Complement-Mediated Neutralization
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DOI: 10.3390/v10050219
Abstract: The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work… read more here.
Keywords: mediated neutralization; complement; piv5; complement mediated ... See more keywords
Atorvastatin suppressed proliferation and facilitated apoptosis of A549 cells through mediating recruitment of Fas and CD59 in lipid raft
Sign Up to like & getrecommendations! Published in 2022 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v22i2.4
Abstract: Purpose: Lipid raft facilitated progression of NSCLC and atorvastatin could break cholesterol. The purpose of this study was to determine the potential mechanism of atorvastatin through lipid raft mediation in NSCLC.Methods: A549 cells were first… read more here.
Keywords: lipid raft; apoptosis; cd59; atorvastatin ... See more keywords