Retinal pigment epithelium and microglia express the CD5 antigen‐like protein, a novel autoantigen in age‐related macular degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2016.12.006
Abstract: Abstract We report on a novel autoantigen expressed in human macular tissues, identified following an initial Western blot (WB)‐based screening of sera from subjects with age‐related macular degeneration (AMD) for circulating auto‐antibodies (AAbs) recognizing macular… read more here.
Keywords: protein; cd5l aim; age related; antigen ... See more keywords
Elevated levels of serum CD5 antigen-like protein distinguish secondary progressive multiple sclerosis from other disease subtypes.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.103269
Abstract: CD5 antigen-like (CD5L) protein is a macrophage-secreted protein with roles in immunomodulation and lipid homeostasis. We compared serum CD5L levels in healthy controls to individuals diagnosed with clinically isolated syndrome, relapsing remitting (RR), secondary progressive… read more here.
Keywords: cd5 antigen; disease; antigen like; multiple sclerosis ... See more keywords
Exogenous CD5L inhibits liver hepatocellular carcinoma cell proliferation and role of CD5L as prognostic marker.
Sign Up to like & getrecommendations! Published in 2023 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000002576
Abstract: BACKGROUND CD5 molecular-like (CD5L) plays an important role in lipid metabolism and immune regulation. This study aimed to investigate the roles of CD5L on liver hepatocellular carcinoma (LIHC). METHODS We analyzed the CD5L mRNA expression… read more here.
Keywords: cell; cell proliferation; expression; cd5l ... See more keywords
CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00480
Abstract: CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to… read more here.
Keywords: cd5l promotes; macrophage polarization; polarization; cd5l ... See more keywords
Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.842996
Abstract: Acute-on chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated cirrhosis (AD). It is characterized by a systemic hyperinflammatory state, leading to multiple organ failure. Our objective was to analyze… read more here.
Keywords: failure; cd5l; lipid mediators; acute chronic ... See more keywords