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   Articles with "cd7" as a keyword



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The clinical importance of CD4+CD7− in human diseases

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27099

Abstract: The CD7 antigen is a member of the immunoglobulin superfamily that expresses on the surface of all thymocytes, a majority of mature T cells, and also natural killer cells. Interestingly, under physiological and different pathological… read more here.

Keywords: clinical importance; cd4 cd7; importance cd4; cd7 ... See more keywords
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111 Highly efficient multiplexed base editing enables development of universal CD7-targeting CAR-T Cells to treat T-ALL

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recommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"

DOI: 10.1136/jitc-2020-sitc2020.0111

Abstract: Background Autologous CAR-T therapies have demonstrated remarkable efficacy in treating some hematologic cancers. However, generating bespoke cell therapies creates manufacturing challenges, inconsistent products, high cost of goods, and delays in treatment that are often incompatible… read more here.

Keywords: base editing; allogeneic car; base; cd7 ... See more keywords
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Engineering Naturally Occurring CD7 Negative Cells for the Immunotherapy of CD7 Positive Leukemia

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-124903

Abstract: Background: CD7 has emerged as a promising target for the adoptive immunotherapy with T-cells expressing chimeric antigen receptors (CAR T-cells) of CD7+ T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). However, expressing CD7… read more here.

Keywords: cd7 carcd7; cd7 cells; carcd7 cells; cd7 ... See more keywords
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Naturally Selected CD7 CAR-T Therapy without Genetic Manipulations for T-ALL/LBL: First-in-human Phase I Clinical Trial.

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recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood.2021014498

Abstract: Derivation of CD7-targeted chimeric antigen receptor (7CAR) T cells often requires genetic manipulations to ablate the CD7 gene or block CD7 cell surface expression. Our novel approach deriving naturally selected 7CAR-T cells (NS7CAR) from bulk… read more here.

Keywords: 7car cells; genetic manipulations; cd7; trial ... See more keywords
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Chimeric Antigen Receptor (CAR) T Cell Therapy for CD7-Positive Acute Myeloid Leukemia

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood.v130.suppl_1.2642.2642

Abstract: Expression of CD7 is an adverse prognostic factor in both AML and myelodysplastic syndromes. Because CD7 is not constitutively expressed by mature myeloid cells or early myeloid progenitor cells, we explored the feasibility of targeting… read more here.

Keywords: cd7; car7 cells; aml; research funding ... See more keywords