Increased expression of CD70 in relapsed acute myeloid leukemia after hypomethylating agents
Sign Up to like & getrecommendations! Published in 2024 at "Virchows Archiv"
DOI: 10.1007/s00428-024-03741-8
Abstract: Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While induction chemotherapy leads to remission in most patients, a significant number will experience relapse. Therefore, there is a need for novel therapies… read more here.
Keywords: expression cd70; cd70; acute myeloid; expression ... See more keywords
Blockade of costimulatory CD27/CD70 pathway promotes corneal allograft survival.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108190
Abstract: PURPOSE To determine whether the CD27/CD70 pathway plays a significant role in corneal allograft rejection by investigating the effect of blocking the CD27/CD70 pathway by anti-CD70 antibody on corneal allograft survival. METHODS Orthotopic penetrating keratoplasty… read more here.
Keywords: corneal allograft; cd70; cd27 cd70; cd70 pathway ... See more keywords
The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.02.015
Abstract: BACKGROUND T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has… read more here.
Keywords: cd70; angiogenesis; stimulation; role ... See more keywords
CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2018.01.024
Abstract: OBJECTIVES In accordance with the Precision Medicine Initiative, new treatment strategies for head and neck squamous cell carcinoma (HNSCC) are needed to yield better therapeutic outcomes. The purpose of this study was to establish and… read more here.
Keywords: neck squamous; cd70; antigen; cell ... See more keywords
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1097-8
Abstract: Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here… read more here.
Keywords: cd70; regulatory cells; determines therapeutic; expression determines ... See more keywords
CD70-Targeted Radiotheranostics: Now and Future.
Sign Up to like & getrecommendations! Published in 2025 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2025.08.001
Abstract: The cluster of differentiation 70 (CD70), a transmembrane glycoprotein encoded by TNFSF7, is a member of the tumor necrosis factor (TNF) superfamily and serves as the ligand for the co-stimulatory receptor CD27. It is aberrantly… read more here.
Keywords: cd70 targeted; cd70; targeted radiotheranostics; tumor ... See more keywords
Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Science"
DOI: 10.1111/cas.16079
Abstract: In CD70‐expressing tumors, the interaction of CD70 on tumor cells with its lymphocyte receptor, CD27, is thought to play a role in immunosuppression in the tumor microenvironment and elevated serum levels of soluble CD27 (sCD27).… read more here.
Keywords: cd70 cd27; cd70; tumor; cd27 interaction ... See more keywords
Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2931
Abstract: CD70 is highly expressed in renal cell carcinoma (RCC), with limited expression in normal tissue, making it an attractive CAR T target for an immunogenic solid tumor indication. Here we generated and characterized a panel… read more here.
Keywords: renal cell; cd70; car; allogeneic ... See more keywords
Abstract 2326: Allo CAR TTMtargeting CD70 for the treatment of renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2326
Abstract: Renal Cell Carcinoma (RCC) represents a substantial patient population, with 65,340 new cases estimated in the US in 2018. Patients with localized tumors undergo nephrectomy, however 30-40% of patients develop metastasis, with a 5-year median… read more here.
Keywords: renal cell; cell carcinoma; treatment; cd70 ... See more keywords
Abstract 891: CD70-targeting CAR-T and CAR-NK cells demonstrate potent activity against NSCLC drug-tolerant persister cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-891
Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the US. Targeted agents, such as EGFR tyrosine kinase inhibitors (TKIs) and KRAS G12C inhibitors, have provided clinical benefits for patients and… read more here.
Keywords: dtpcs; cd70; car; car cells ... See more keywords
Abstract 5629: MEF2D regulates T cell function via the CD70-CD27 signaling axis and promotes immune escape in hepatocellular carcinomas
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5629
Abstract: Background: Immune escape remains a challenge in the treatment of hepatocellular carcinoma (HCC), one of the most common and deadly cancers in the world. The transcription factor, myocyte enhancer factor 2D (MEF2D), is important in… read more here.
Keywords: mef2d; cd70 cd27; cd70; function ... See more keywords