Blockade of costimulatory CD27/CD70 pathway promotes corneal allograft survival.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108190
Abstract: PURPOSE To determine whether the CD27/CD70 pathway plays a significant role in corneal allograft rejection by investigating the effect of blocking the CD27/CD70 pathway by anti-CD70 antibody on corneal allograft survival. METHODS Orthotopic penetrating keratoplasty… read more here.
Keywords: corneal allograft; cd70; cd27 cd70; cd70 pathway ... See more keywords
The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.02.015
Abstract: BACKGROUND T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has… read more here.
Keywords: cd70; angiogenesis; stimulation; role ... See more keywords
CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2018.01.024
Abstract: OBJECTIVES In accordance with the Precision Medicine Initiative, new treatment strategies for head and neck squamous cell carcinoma (HNSCC) are needed to yield better therapeutic outcomes. The purpose of this study was to establish and… read more here.
Keywords: neck squamous; cd70; antigen; cell ... See more keywords
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1097-8
Abstract: Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here… read more here.
Keywords: cd70; regulatory cells; determines therapeutic; expression determines ... See more keywords
Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2931
Abstract: CD70 is highly expressed in renal cell carcinoma (RCC), with limited expression in normal tissue, making it an attractive CAR T target for an immunogenic solid tumor indication. Here we generated and characterized a panel… read more here.
Keywords: renal cell; cd70; car; allogeneic ... See more keywords
Abstract 2326: Allo CAR TTMtargeting CD70 for the treatment of renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2326
Abstract: Renal Cell Carcinoma (RCC) represents a substantial patient population, with 65,340 new cases estimated in the US in 2018. Patients with localized tumors undergo nephrectomy, however 30-40% of patients develop metastasis, with a 5-year median… read more here.
Keywords: renal cell; cell carcinoma; treatment; cd70 ... See more keywords
Abstract 891: CD70-targeting CAR-T and CAR-NK cells demonstrate potent activity against NSCLC drug-tolerant persister cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-891
Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the US. Targeted agents, such as EGFR tyrosine kinase inhibitors (TKIs) and KRAS G12C inhibitors, have provided clinical benefits for patients and… read more here.
Keywords: dtpcs; cd70; car; car cells ... See more keywords
CD70-specific CAR T-cells have potent activity against Acute Myeloid Leukemia (AML) without HSC toxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020008221
Abstract: The prognosis of patients with acute myeloid leukemia (AML) remains dismal highlighting the need for novel innovative treatment strategies. The application of chimeric antigen receptor (CAR) T-cell therapy to AML patients has been limited in… read more here.
Keywords: cd70; myeloid leukemia; acute myeloid; car cells ... See more keywords
Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18202
Abstract: In contrast to the negligible expression of the immunomodulating protein CD70 in normal tissue, we have demonstrated constitutive overexpression of CD70 on tumor cells in a subset of primary non-small cell lung cancer (NSCLC) biopsies.… read more here.
Keywords: combination; cd70; lung cancer; therapy ... See more keywords
CD70 Modulates Thymocyte Development and Type 1 Diabetes in NOD Mice
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-320-or
Abstract: CD70 is a tumor necrosis factor (TNF) superfamily member expressed by activated T cells, B cells, dendritic cells, NK cells and mature macrophages. It interacts with CD27, a TNF receptor family member on T cells… read more here.
Keywords: cd70; type diabetes; cell; development ... See more keywords
CD70 in Thymic Squamous Cell Carcinoma: Potential Diagnostic Markers and Immunotherapeutic Targets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.808396
Abstract: CD70 – a ligand protein of CD27 on lymphocytes – is expressed in a large spectrum of malignancies. It is an attractive target for antibody-based therapy and several clinical trials are currently being conducted. However,… read more here.
Keywords: cell carcinoma; thymic squamous; squamous cell; cd70 ... See more keywords