Abstract B048: A Promising Pathway in Immuno-oncology: CD73-Adenosine axis highlighted by quantitative mass spectrometry imaging
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DOI: 10.1158/1535-7163.targ-19-b048
Abstract: Introduction: The CD73-Adenosine (CD73-ADO) axis constitutes one of the most promising pathways in immuno-oncology. CD73 catalyzes the conversion of adenosine monophosphate (AMP) to ADO. CD73 is believed to play a role in mediating the inhibitory… read more here.
Keywords: cd73; immuno oncology; cd73 adenosine; tumor ... See more keywords
The metabolic milieu in melanoma: Role of immune suppression by CD73/adenosine
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DOI: 10.1177/1010428319837138
Abstract: The mechanisms leading to immune escape of melanoma have been largely investigated in relation to its tumour immunogenicity and features of inflamed microenvironment that promote the immune suppression during the disease progression. These findings have… read more here.
Keywords: melanoma; cd73 adenosine; immune suppression; milieu ... See more keywords
Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy
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DOI: 10.3389/fimmu.2019.00698
Abstract: Extracellular adenosine is a potent endogenous immunosuppressive mediator critical to the maintenance of homeostasis in various normal tissues including the lung. Adenosine is either released from stressed or injured cells or generated from extracellular adenine… read more here.
Keywords: cd73 adenosine; radiotherapy; tissue; cd73 ... See more keywords