Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1744946
Abstract: ABSTRACT Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important pathway of immune suppression in the tumor microenvironment. Using two mouse models (RET transgenic melanoma and Panc02 orthotopic pancreatic adenocarcinoma), we… read more here.
Keywords: expression; cd73; cd73 cells; expression cd39 ... See more keywords
CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming
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DOI: 10.1161/circulationaha.116.023365
Abstract: Background: T cells are required for proper healing after myocardial infarction. The mechanism of their beneficial action, however, is unknown. The proinflammatory danger signal ATP, released from damaged cells, is degraded by the ectonucleotidases CD39… read more here.
Keywords: cd73 cells; cardiac wound; myocardial infarction; cd73 ... See more keywords
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B
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DOI: 10.1371/journal.pone.0238493
Abstract: To better understand anti-malaria protective immune responses, we examined the cellular mechanisms that govern protective immunity in a murine Plasmodium yoelii 17X NL (PyNL) re-infection model. Initially, we confirmed that immune B cells generated during… read more here.
Keywords: cd73 cells; infection; pynl infection; cd73 ... See more keywords
The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1110325
Abstract: Hematological malignancy develops and applies various mechanisms to induce immune escape, in part through an immunosuppressive microenvironment. Adenosine is an immunosuppressive metabolite produced at high levels within the tumor microenvironment (TME). Adenosine signaling through the… read more here.
Keywords: ectonucleotidases cd39; cd39 cd73; cd73 cells; hematological malignancy ... See more keywords