Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF‐β production
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3742
Abstract: Recently, a link between the biological activity of CD73 and tumorigenicity in solid tumors has been proposed. We previously reported that the generation of adenosine (Ado) by the activity of CD73 in cervical cancer (CC)… read more here.
Keywords: caski cells; cervical cancer; increase; expression ... See more keywords
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09775-w
Abstract: Glioblastoma (GBM) is the most malignant and deadly brain tumor. GBM cells overexpress the CD73 enzyme, which controls the level of extracellular adenosine, an immunosuppressive molecule. Studies have shown that some nonsteroidal anti-inflammatory drugs (NSAIDs)… read more here.
Keywords: nsaids methotrexate; cd73 expression; expression; gbm cells ... See more keywords
CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08123-8
Abstract: Agonist antibodies (Ab) directed against costimulatory molecules on the surface of antigen-primed T cells are in various stages of pre-clinical and clinical trials, albeit with limited therapeutic benefit as single agents. The underlying mechanisms of… read more here.
Keywords: anti 1bb; therapy; resistance anti; cd73 expression ... See more keywords
CD73 expression in lymph node metastases in patients with head and neck cancer
Sign Up to like & getrecommendations! Published in 2018 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2017.1378436
Abstract: Abstract Introduction: CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall… read more here.
Keywords: cd73 expression; lymph; expression; cancer ... See more keywords
Prognostic value of CD73 expression in resected colorectal cancer liver metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1746138
Abstract: ABSTRACT Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether CD73, the… read more here.
Keywords: colorectal cancer; cd73; liver; cd73 expression ... See more keywords
Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC
Sign Up to like & getrecommendations! Published in 2020 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13346
Abstract: CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance. Although CD73 overexpression has been reported to be a poor prognostic factor in several malignancies including non‐small… read more here.
Keywords: immune checkpoint; cd73; cd73 expression; checkpoint inhibitors ... See more keywords
Abstract LB-282: Dynamic regulation of CD73 expression in cancer associated fibroblasts enforces immunosuppression via a feedforward adenosinergic pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-lb-282
Abstract: CD73 is the major extracellular adenosine-generating ecto-59-nucleotidase (Nt5e) that metabolizes extracellular (e) AMP and generates immunosuppressive adenosine (eADO). Elevated CD73 expression is often exploited by tumors and other cellular constituents of the tumor microenvironment (TME)… read more here.
Keywords: cancer associated; cd73; cd73 expression; tme ... See more keywords
Abstract 1012: Determinants of immune evasion inMETdriven lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-1012
Abstract: PURPOSE: The 59 ectonucleotidase (NT5E) encodes for the CD73 membrane protein that converts the extracellular AMP into adenosine (Ado), an immunosuppressive nucleoside that generates anti-inflammatory responses by stimulating T cell anergy. We aimed to analyze… read more here.
Keywords: cd73 expression; immune evasion; cd73; lung cancer ... See more keywords
Prognostic significance of CD73 expression in localized renal cell carcinoma (RCC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.4582
Abstract: 4582 Background: CD73 or ecto-5'-nucleotidase mediates the de-phosphorylation of adenosine monophosphate to adenosine which promotes immunosuppression in the tumor microenvironment. Its prognostic significance in localized RCC has not been well characterized. Methods: We assessed CD73… read more here.
Keywords: expression; cd73 expression; tumor; cell ... See more keywords
CD73 expression and clinical significance in human metastatic melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25426
Abstract: Background CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target. Results CD73 expression was detected in TC in 54% of… read more here.
Keywords: metastatic melanoma; timc; cd73 expression; expression ... See more keywords
CD73 Severed as a Potential Prognostic Marker and Promote Lung Cancer Cells Migration via Enhancing EMT Progression
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.728200
Abstract: To investigate the expression levels and prognostic value of CD73 in lung cancer. And moreover, to identify the effect and potential mechanism of CD73 on lung cancer cells proliferation and migration. CD73 expression levels in… read more here.
Keywords: cd73 expression; migration; cd73; lung cancer ... See more keywords