Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103023
Abstract: Short peptides reflecting major histocompatibility complex (MHC) class I (MHC-I) epitopes frequently lack sufficient immunogenicity to induce robust antigen (Ag)-specific CD8+ T cell responses. In the current work, it is demonstrated that position-scanning peptide libraries… read more here.
Keywords: cd8 cell; cell responses; cd8; position scanning ... See more keywords
Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207499
Abstract: Natural killer (NK) cells not only are innate effector lymphocytes that directly participate in tumor surveillance but are also essential helpers in the antitumor CD8+ T‐cell response. However, the molecular mechanisms and potential checkpoints regulating… read more here.
Keywords: cell; response; antitumor cd8; helper functions ... See more keywords
Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates
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DOI: 10.1002/advs.202414931
Abstract: Clinical trials of receptor‐biased interleukin‐2 (IL‐2) variants in cancer therapy show limited efficacy. To investigate, we re‐evaluated divergent receptor‐biased IL‐2 PEGylates (generated via site‐specific PEGylation at residues D20 (not‐β) and Y45 (not‐α)), alone or in… read more here.
Keywords: divergent receptor; receptor biased; cd8 cells; cd8 ... See more keywords
MARCO+ Tumor-Associated Macrophages Impede CD8+ T Cell Immunity to Facilitate Immunotherapy Resistance in Renal Cell Carcinoma.
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DOI: 10.1002/advs.202514600
Abstract: Immune checkpoint blockade (ICB) therapy, especially in combination regimens, has significantly increased survival of renal cell carcinoma (RCC) patients. However, the ICB‐resistant mechanisms remain largely unclear and require further investigation. Here, an immunosuppressive ecosystem in… read more here.
Keywords: cd8; cell; tumor; marco tumor ... See more keywords
Light Metabolically Reprograms CD8+ T Cells to Potentiate STING-Driven Tumor Eradication and Prevent Metastasis.
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DOI: 10.1002/advs.202515121
Abstract: Immunotherapy remains ineffective in many solid tumors due to poor T‐cell infiltration and a metabolically suppressive tumor microenvironment. A dual strategy combining low‐level light (LLL) therapy with a nanoscale stimulator of interferon genes (STING) agonist… read more here.
Keywords: tumor eradication; cd8; tumor; cell ... See more keywords
Spatial cytotoxic and memory T cells in tumor predict superior survival outcomes in patients with high‐grade serous ovarian cancer
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DOI: 10.1002/cam4.3942
Abstract: Although the association between tumor‐infiltrating CD3+ T and CD8+ T cells and superior survival in high‐grade serous ovarian cancer (HGSOC) has been observed, the different spatial localization of tumor‐infiltrating lymphocytes (TILs) possesses heterogeneous effects. We… read more here.
Keywords: grade serous; cd8; high grade; cancer ... See more keywords
Clinical significance of CD8-positive lymphocytes on tumor cell clusters of ascites cell block in ovarian high-grade serous carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4592
Abstract: BACKGROUND The clinical significance of CD8-positive (CD8+ ) lymphocytes on tumor cell clusters of ascites cell blocks in patients with ovarian high-grade serous carcinoma (HGSC) was investigated. METHODS Among HGSC patients who underwent surgery from… read more here.
Keywords: group; cd8; cd8 lymphocytes; cell ... See more keywords
OMIP‐079: Cell cycle of CD4+ and CD8+ naïve/memory T cell subsets, and of Treg cells from mouse spleen
Sign Up to like & getrecommendations! Published in 2021 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24509
Abstract: A multicolor flow cytometry panel was designed and optimized to define the following nine mouse T cell subsets: Treg (CD3+ CD4+ CD8− FoxP3+), CD4+ T naïve (CD3+ CD4+ CD8−FoxP3− CD44int/low CD62L+), CD4+ T central memory… read more here.
Keywords: cd4; cd3; cd62l; cd8 ... See more keywords
Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice *
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DOI: 10.1002/eji.201747091
Abstract: The ability of different CD4+ T cell subsets to help CD8+ T‐cell response is not fully understood. Here, we found using the murine system that Th17 cells induced by IL‐1β, unlike Th1, were not effective… read more here.
Keywords: deviation; cd8; response; cd4 cell ... See more keywords
Hyaluronan‐binding by CD44 reduces the memory potential of activated murine CD8 T cells
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DOI: 10.1002/eji.201747263
Abstract: Expansion and death of effector CD8 T cells are regulated to limit immunopathology and cells that escape contraction go on to generate immunological memory. CD44, a receptor for the extracellular matrix component hyaluronan, is a… read more here.
Keywords: cd8; binding cd44; cd8 cells; hyaluronan binding ... See more keywords
Skin‐homing CD8+ T cells preferentially express GPI‐anchored peptidase inhibitor 16, an inhibitor of cathepsin K
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847552
Abstract: This study sought to identify novel CD8+ T cell homing markers by studying acute graft versus host disease (aGvHD), typically involving increased T cell homing to the skin and gut. FACS‐sorted skin‐homing (CD8β+/CLA+), gut‐homing (CD8β+/integrinβ7+),… read more here.
Keywords: homing cd8; inhibitor; cd8; cd8 cells ... See more keywords