A soluble activator that favors the ex vivo expansion of CD8+CD27+ T cells
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DOI: 10.1172/jci.insight.141293
Abstract: Adoptive cell therapy involves the infusion of tumor-reactive T cells into patients with cancer to provide antitumor immunity. The ex vivo expansion and differentiation of such T cells are key parameters that affect their therapeutic… read more here.
Keywords: vivo expansion; expansion; cd28; cell ... See more keywords
Novel Natural Ligand Chimeric Antigen Receptors (CARs) Targeting CD70 with a Redesigned CD27 Binding Interface Provide Enhanced Potency Against Acute Myeloid Leukemia
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DOI: 10.1182/blood-2024-204895
Abstract: Introduction: Chimeric antigen receptor (CAR) T cell therapies have brought tremendous progress in the treatment of B lymphoid and plasma cell malignancies, but development for acute myeloid leukemia (AML) has been difficult. CD70 is an… read more here.
Keywords: binding interface; car; leukemia; cd8 cd27 ... See more keywords