Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8+ T Cell Responses
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201700426
Abstract: Abstract Due to its safety and efficacy, aluminum hydroxide is used as an immune adjuvant in human vaccines for over 80 years. Being a Th2 stimulator, the classical gel‐like adjuvant, however, fails to generate CD8+… read more here.
Keywords: cd8 cell; cell responses; turning old; gel ... See more keywords
Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103023
Abstract: Short peptides reflecting major histocompatibility complex (MHC) class I (MHC-I) epitopes frequently lack sufficient immunogenicity to induce robust antigen (Ag)-specific CD8+ T cell responses. In the current work, it is demonstrated that position-scanning peptide libraries… read more here.
Keywords: cd8 cell; cell responses; cd8; position scanning ... See more keywords
Immunopathology caused by impaired CD8+ T‐cell responses
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149528
Abstract: Recent findings indicate that many immunopathologies are at their roots a consequence of impaired immune responses (“too little” immunity) and not the result of primarily exaggerated immune responses (“too much” immunity). We have summarized this… read more here.
Keywords: cell; immunopathology; cd8 cell; caused impaired ... See more keywords
CD4+Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T‐cell suppression during chronic liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28894
Abstract: Persistent hepatotropic viral infections are a common etiologic agent of chronic liver disease. Unresolved infection can be attributed to nonfunctional intrahepatic CD8+ T‐cell responses. In light of dampened CD8+ T‐cell responses, liver disease often manifests… read more here.
Keywords: liver disease; cell; cd4; cd8 cell ... See more keywords
Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32084
Abstract: Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete tumor desialylation on anti‐tumor immunity… read more here.
Keywords: cd8 cell; tumor; cancer; cell ... See more keywords
Tumor-Specific CD8+ T-Cell Responses Induced by DNA Vaccination.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0872-2_12
Abstract: DNA vaccines assisted by electroporation efficiently trigger antitumor cytotoxic CD8+ T cell responses in preclinical cancer models and hold potential for human use. They can be easily engineered to express either tumor-associated self-antigens, which are… read more here.
Keywords: cd8 cell; cell responses; tumor specific; tumor ... See more keywords
Differentiation of Diverse Progenies of Memory T Cells from Naïve CD8+ T Cell Precursors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6548-9_8
Abstract: Following recognition of the cognate antigen, naïve T cells differentiate in a diverse progeny of memory T cells which differ at the phenotypic, gene expression and metabolic level. These molecular differences are at the basis… read more here.
Keywords: cd8 cell; cell precursors; memory cells; differentiation diverse ... See more keywords
GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02441-6
Abstract: Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency in T-cells is detected by GCN2 kinase, which through phosphorylation of EIF2α,… read more here.
Keywords: cd8 cell; cd8; gcn2; cd8 cells ... See more keywords
Chromatin accessibility of CD8 T cell differentiation and metabolic regulation
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-020-09546-0
Abstract: CD8 + T cells play an important role in controlling infections and tumorigenesis in vivo. naïve CD8 + T cells exponentially expand and exert effector functions in response to TCR ligation. After antigen clearance, most… read more here.
Keywords: cd8 cell; cd8; chromatin; accessibility ... See more keywords
Interleukin-35 Suppresses CD8+ T Cell Activity in Patients with Viral Hepatitis-Induced Acute-on-Chronic Liver Failure
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06077-w
Abstract: Interleukin (IL)-35 is a newly indentified cytokine and induces immunotolerance via suppression of CD8+ T cell activity in chronic viral hepatitis. To investigate the modulatory function of IL-35 to CD8+ T cells in viral hepatitis-induced… read more here.
Keywords: cd8 cell; cd8; cd8 cells; viral hepatitis ... See more keywords
A CD8+ T Cell-Related Genes Expression Signature Predicts Prognosis and the Efficacy of Immunotherapy in Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-022-09510-0
Abstract: Immunotherapy has been applied to patients with breast cancer. However, only part of patients benefits from the current immunotherapy. Accurate prediction of individual response to immunotherapy can be beneficial for breast cancer management. CD8+ T… read more here.
Keywords: risk; expression; breast cancer; cd8 cell ... See more keywords