Tertiary lymphoid structures in head and neck squamous cell carcinoma improve prognosis by recruiting CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13403
Abstract: Tertiary lymphoid structures (TLSs) are formed in long-term chronic inflammation, promoting the local recruitment of lymphocytes, antigen presentation, and regulation of immune response, correlated with a better prognosis for cancer patients. Although studies have been… read more here.
Keywords: cell; prognosis; lymphoid structures; cd8 cells ... See more keywords
Single‐Cell Transcriptomics Reveals Longevity Immune Remodeling Features Shared by Centenarians and Their Offspring
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204849
Abstract: Centenarians, who show mild infections and low incidence of tumors, are the optimal model to investigate healthy aging. However, longevity related immune characteristics has not been fully revealed largely due to lack of appropriate controls.… read more here.
Keywords: cell; immune remodeling; longevity; centenarians offspring ... See more keywords
BETi – Are all BETs off in the clinic?
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202300027
Abstract: Targeting of bromoand extra-terminal domain (BET) motifs has been a heavily investigated area for therapeutic intervention for some time, and despite intensive efforts have yet to be approved for clinical use.[1] Andwhile a significant quantity… read more here.
Keywords: cell; bets clinic; resistance; cd8 cells ... See more keywords
Hyaluronan‐binding by CD44 reduces the memory potential of activated murine CD8 T cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747263
Abstract: Expansion and death of effector CD8 T cells are regulated to limit immunopathology and cells that escape contraction go on to generate immunological memory. CD44, a receptor for the extracellular matrix component hyaluronan, is a… read more here.
Keywords: cd8; binding cd44; cd8 cells; hyaluronan binding ... See more keywords
Skin‐homing CD8+ T cells preferentially express GPI‐anchored peptidase inhibitor 16, an inhibitor of cathepsin K
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847552
Abstract: This study sought to identify novel CD8+ T cell homing markers by studying acute graft versus host disease (aGvHD), typically involving increased T cell homing to the skin and gut. FACS‐sorted skin‐homing (CD8β+/CLA+), gut‐homing (CD8β+/integrinβ7+),… read more here.
Keywords: homing cd8; inhibitor; cd8; cd8 cells ... See more keywords
CCR4+CD8+ T cells clonally expand to differentiated effectors in murine psoriasis and in human psoriatic arthritis
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202149702
Abstract: Psoriasis is a chronic inflammatory skin disease with an autoimmune component and associated with joint inflammation in up to 30% of cases. To investigate autoreactive T cells, we developed an imiquimod‐induced psoriasis‐like inflammation model in… read more here.
Keywords: psoriasis; psoriatic arthritis; cd8 cells; ccr4 ... See more keywords
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149781
Abstract: The RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) has been found to have roles in CD4 T cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for… read more here.
Keywords: activation; cd8 cells; polypyrimidine tract; cd8 ... See more keywords
Memory CD8+ T cells upregulate glycolysis and effector functions under limiting oxygen conditions
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249918
Abstract: Memory CD8+ T cells are indispensable for maintaining long‐term immunity against intracellular pathogens and tumors. Despite their presence at oxygen‐deprived infected tissue sites or in tumors, the impact of local oxygen pressure on memory CD8+… read more here.
Keywords: oxygen pressure; memory cd8; cd8 cells; cd8 ... See more keywords
Innate‐like bystander‐activated CD38+HLA‐DR+CD8+T cells play a pathogenic role in patients with chronic hepatitis C
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32349
Abstract: HCV‐specific T cells are few and exhausted in patients with chronic hepatitis C (CHC). Whether these T cells are responsible for the liver damage and fibrosis is still debated. However, cluster of differentiation 38–positive (CD38+)… read more here.
Keywords: patients chronic; chronic hepatitis; cd8 cells; hla cd8 ... See more keywords
NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cancer"
DOI: 10.1002/ijc.33859
Abstract: The surface inhibitory receptor NKG2A forms heterodimers with the invariant CD94 chain and is expressed on a subset of activated CD8 T cells. As antibodies to block NKG2A are currently tested in several efficacy trials… read more here.
Keywords: cd8; inhibitory receptor; cd8 cells; nkg2a late ... See more keywords
Genome‐wide expression profiling analysis to identify key genes in the anti‐HIV mechanism of CD4+ and CD8+ T cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25071
Abstract: Comprehensive bioinformatics analyses were performed to explore the key biomarkers in response to HIV infection of CD4+ and CD8+ T cells. The numbers of CD4+ and CD8+ T cells of HIV infected individuals were analyzed… read more here.
Keywords: anti hiv; hiv infection; cd8 cells; cd4 cd8 ... See more keywords