The effect of SMAD4 on the prognosis and immune response in hypopharyngeal carcinoma
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DOI: 10.3389/fmed.2023.1139203
Abstract: Objectives In malignant tumors, elevated infiltration of intratumoral CD8+ cytotoxic T cells predicts a beneficial prognosis, whereas high levels of CD15+ neutrophils in peritumor tissues indicate poor prognosis. It is unclear how SMAD4, which promotes… read more here.
Keywords: prognosis; cd15 neutrophils; cd8 cytotoxic; cytotoxic ... See more keywords
The Association of CD8+ Cytotoxic T Cells and Granzyme B+ Lymphocytes with Immunosuppressive Factors, Tumor Stage and Prognosis in Cutaneous Melanoma
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DOI: 10.3390/biomedicines10123209
Abstract: The immunosuppressive tumor microenvironment (TME) consists of suppressive cells producing a variety of immunomodulatory proteins, such as programmed death ligand 1 (PD-L1) and indoleamine-2,3-dioxygenase (IDO). Although granzyme B (GrB) is known to convey the cytolytic… read more here.
Keywords: grb lymphocytes; melanoma; cd8 cytotoxic; immunosuppressive factors ... See more keywords