CD8+iTregs attenuate glomerular endothelial cell injury in lupus‐prone mice through blocking the activation of p38 MAPK and NF‐&kgr;B
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.09.006
Abstract: HIGHLIGHTSLPS increased MRL/lpr mice glomerular endothelial cells (lupus‐MGECs) apoptosis and adhesion of monocytes to lupus‐MGECs.CD8+iTregs attenuated lupus‐MGECs apoptosis and inhibited adhesion of monocytes to lupus‐MGECs.CD8+iTregs attenuated LPS‐induced lupus‐MGECs injury through blocking the activation of p38… read more here.
Keywords: kgr; cd8 itregs; lupus mgecs; adhesion ... See more keywords
Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000531
Abstract: Adoptive transfer of induced regulatory T cells (iTregs) can ameliorate graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). CD4+ iTregs can effectively prevent GVHD but impair the graft-versus-leukemia (GVL) effect, whereas CD8+ iTregs preserve… read more here.
Keywords: cd8 itregs; vit; leukemia; gvhd ... See more keywords