Genetically driven CD39 expression shapes human tumor‐infiltrating CD8+ T‐cell functions
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DOI: 10.1002/ijc.33131
Abstract: In our study, we investigated the role of CD39 on tumor‐infiltrating CD8+ T lymphocytes (CD8+ TILs) in colorectal, head and neck and pancreatic cancers. Partially confirming recent observations correlating the CD39 expression with T‐cell exhaustion,… read more here.
Keywords: cd8; cd8 tils; expression; cd39 cd8 ... See more keywords
Clinical Efficacy of Osimertinib Mesylate Tablets in Treatment of Advanced NSCLC: P048
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DOI: 10.1016/j.jtho.2018.10.070
Abstract: expressed, PD-L1 was up-regulated in NSCLC compared with the adjacent tissues. CD8+ TILs could be seen in tumor stroma and nest. With univariate analysis, we found that the down-expression of MHC-I had an association with… read more here.
Keywords: mhc cd8; cd8 cd8; cd8; group ... See more keywords
The Prognostic Value of Tumor-Infiltrating lymphocytes in Stage II Colon Cancer. A Nationwide Population-Based Study1
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DOI: 10.1016/j.tranon.2018.03.008
Abstract: BACKGROUND: Additional prognostic markers are needed for better treatment stratification of stage II colon cancer (CC). We investigated the prognostic value of tumor-infiltrating lymphocytes (TILs) in a true population-based cohort of patients with stage II… read more here.
Keywords: prognostic value; cd8 tils; cd3 cd8; stage ... See more keywords
Association between CD8+ tumor-infiltrating lymphocytes and prognosis of non-small cell lung cancer patients treated with PD-1/PD-L1 inhibitors: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2023.2208351
Abstract: ABSTRACT Background A meta-analysis method was used to investigate the prognostic value of CD8+ tumor-infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC) patients treated with PD-1/PD-L1 inhibitors. Methods A database search of PubMed, Embase,… read more here.
Keywords: meta analysis; patients treated; treated inhibitors; cd8 tils ... See more keywords
PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2020 at "International immunology"
DOI: 10.1093/intimm/dxaa010
Abstract: Persistent exposure to tumor antigens results in exhausted tumor-infiltrating T cells (TILs) that express the immune checkpoint molecules, PD-1 and Tim3, and lack anti-tumor immunity. To examine the exhausted status of TILs in ovarian cancer,… read more here.
Keywords: cd8 tils; ovarian cancer; cd8; tim3 cd8 ... See more keywords
DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002671
Abstract: Background Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for predicting immunotherapy responsiveness and survival outcome. However, the evaluation of CD8+ TILs currently relies on histopathological methodology with high variability. We therefore aimed to… read more here.
Keywords: cd8; cd8 metil; cd8 tils; signature ... See more keywords
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens
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DOI: 10.1136/jitc-2021-002709
Abstract: Background CD8+ tumor-infiltrating lymphocytes (TILs) comprise phenotypically and functionally heterogeneous subpopulations. Of these, effector memory CD45RA re-expressing CD8+ T cells (Temra) have been discovered and characterized as the most terminally differentiated subset. However, their exact… read more here.
Keywords: cd8; tumor antigens; immunogenicity tumor; cd8 tils ... See more keywords
Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003667
Abstract: Background Novel therapies are needed to treat recurrent and advanced cervical cancer (CC), as their prognosis remains very poor. Although therapies targeting the programmed cell death protein 1 (PD-1) pathway have been approved for CC,… read more here.
Keywords: cancer; cd8 tils; function; cd8 ... See more keywords
Abstract 4647: Potential of TIMP3 regulating the versican status in the colorectal cancer tumor microenvironment
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DOI: 10.1158/1538-7445.am2023-4647
Abstract: Background: In colorectal cancer (CRC), versican (VCAN) accumulation has been found to negatively correlate with CD8+ tumor infiltrating lymphocyte (TIL) abundance and its proteolysis into versikine (Vkine) positively correlates with TIL abundance. TIMP3 has demonstrated… read more here.
Keywords: timp3; vkine; cd8 tils; tumor ... See more keywords
Abstract 608: Low avidity neoepitope-specific CD8+ tumor infiltrating lymphocytes are less exhausted and more effective than their high avidity counterparts in a BALB/c murine fibrosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-608
Abstract: The frequency of CD8+ tumor infiltrating lymphocytes (TILs) has been positively associated with overall survival in several cancers. The interaction of T cell receptors (TCRs) on T cells with Major Histocompatibility Complex (MHC)-peptide complexes on… read more here.
Keywords: low avidity; high avidity; term; cd8 tils ... See more keywords
Abstract 6424: Immune characteristics and anti-PD-1-induced reinvigoration capacity of tumor-infiltrating lymphocytes in ovarian clear cell carcinoma relative to high-grade serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6424
Abstract: Recent clinical trials have demonstrated the potential efficacy of immune checkpoint inhibitors (ICIs) for ovarian clear cell carcinoma (OCCC). However, little is known about the immune characteristics of OCCC. In this study, we aimed to… read more here.
Keywords: immune characteristics; cd8 tils; tumor infiltrating; carcinoma ... See more keywords