Altered levels of circulating CD8+CXCR5+PD-1+T follicular cytotoxic cells in primary Sjögren’s syndrome
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DOI: 10.1007/s10067-022-06098-y
Abstract: Circulating CD8+ T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) (CD8+CXCR5+T), a recently identified follicular cytotoxic T cell subset, are involved in antiviral immunity and autoimmunity, but their abundance and role in the pathogenesis… read more here.
Keywords: cd8 treg; cd8 cxcr5; cd8; pss patients ... See more keywords
CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15857-x
Abstract: Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying… read more here.
Keywords: cd8 treg; treg cells; autoimmune; cd8 regulatory ... See more keywords
Host Expression of the CD8 Treg/NK Cell Restriction Element Qa-1 is Dispensable for Transplant Tolerance
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DOI: 10.1038/s41598-017-11780-2
Abstract: Disruption of the non-classical Major Histocompatibility Complex (MHC) Ib molecule Qa-1 impairs CD8 Treg and natural killer (NK) cell function and promotes a lupus-like autoimmune disease. This immune perturbation would be expected to enhance anti-transplant… read more here.
Keywords: cd8 treg; transplant tolerance; cell; transplant ... See more keywords