Inhibition of hepatitis C virus genotype 4 replication using siRNA targeted to the viral core region and the CD81 cellular receptor
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01077-1
Abstract: Hepatitis C virus (HCV) is one of the most important causative agents of hepatitis worldwide. The current study aimed to evaluate the silencing effect of the small interference RNA (siRNA) molecules designed against the core… read more here.
Keywords: cellular receptor; hcv; core region; cd81 ... See more keywords
Structural insights into hepatitis C virus receptor binding and entry.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03913-5
Abstract: Hepatitis C virus (HCV) infection is a causal agent of chronic liver disease, cirrhosis and hepatocellular carcinoma in humans, and afflicts more than 70 million people worldwide. The HCV envelope glycoproteins E1 and E2 are responsible… read more here.
Keywords: cd81 lel; cd81; receptor binding; hepatitis virus ... See more keywords
Flow cytometric expression of CD71, CD81, CD44 and CD39 in B cell lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2021.1929446
Abstract: Abstract Flow cytometry is a useful ancillary tool for the diagnosis of nodal B cell lymphomas. Well-established antigens have diagnostic limitations. This study aimed to assess the expression of CD71, CD81, CD44 and CD39 by… read more here.
Keywords: cd81; cell lymphoma; cd71; expression ... See more keywords
Improved Recognition of Hematogones From Precursor B-Lymphoblastic Leukemia by a Single Tube Flow Cytometric Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqaa007
Abstract: OBJECTIVES To improve diagnostic accuracy in differentiating hematogones from leukemic blasts in cases of precursor B-lymphoblastic leukemia/lymphoma (B-ALL), particularly those that are posttreatment or after bone marrow transplant, and to provide an algorithmic approach to… read more here.
Keywords: lymphoblastic leukemia; precursor lymphoblastic; cd81; cd58 ... See more keywords
The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00731-22
Abstract: In this study, we discover the tetraspanin CD81 as a host factor for the globally emerging chikungunya virus and related alphaviruses. We show that CD81 promotes replication of viral genomes in human and mouse cells,… read more here.
Keywords: cd81; replication; virus; host factor ... See more keywords
Screening of EWI-2-Derived Peptides for Targeting Tetraspanin CD81 and Their Effect on Cancer Cell Migration
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030510
Abstract: CD81, a transmembrane protein belonging to the tetraspanin family, has recently been suggested as a therapeutic target for cancers. Here, we screened peptides that bind to the tetraspanin CD81 protein, and evaluated their inhibitory activity… read more here.
Keywords: cd81; cell migration; cancer; cancer cell ... See more keywords
CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13091998
Abstract: Simple Summary CD81 is highly expressed in glioblastoma (GBM) as a transmembrane protein. The functional study demonstrated that CD81 contributed to radioresistance of GBM. Further evidence showed that CD81 expression was closely related to DNA… read more here.
Keywords: glioblastoma; dna; gbm; radioresistance ... See more keywords
Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15072186
Abstract: Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets, notably the transmembrane protein CD81 which has been structurally well characterized.… read more here.
Keywords: cd81; cancers viral; viral diseases; cd81 monoclonal ... See more keywords